2-((4-(4-Chlorophenyl)-5-(4-methoxyphenyl)-4H-1,2,4-triazol-3-yl)thio)-N-(o-tolyl)acetamide CAS 476484-52-3
| CAS No. | 476484-52-3 |
| Molecular Formula | C24H21ClN4O2S |
| Molecular Weight | 464.97 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2-((4-(4-Chlorophenyl)-5-(4-methoxyphenyl)-4H-1,2,4-triazol-3-yl)thio)-N-(o-tolyl)acetamide (CAS 476484-52-3), molecular formula C24H21ClN4O2S and molecular weight 464.97 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 2-((4-(4-Chlorophenyl)-5-(4-methoxyphenyl)-4H-1,2,4-triazol-3-yl)thio)-N-(o-tolyl)acetamide (C24H21ClN4O2S) is characterized by a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 2-((4-(4-Chlorophenyl)-5-(4-methoxyphenyl)-4H-1,2,4-triazol-3-yl)thio)-N-(o-tolyl)acetamide under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C24H21ClN4O2S |
| Molecular Weight | 464.97 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
| Sulfur Atoms | 1 |
Related Chlorophenyl Standards
- 2-((5-(2-Chlorophenyl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)-N-(4-ethoxyphenyl)acetamide (CAS 332948-88-6)
- 1-(4-Chlorophenyl)-4-{[2-(3,5-dimethyl-1H-pyrazole-1-carbonyl)thiophen-3-yl]sulfonyl}piperazine (CAS 1171812-17-1)
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- N-(4-((4-chlorophenyl)sulfonyl)-3-cyanophenyl)-3-(trifluoromethyl)benzamide (CAS 306980-65-4)
Recommended Standards
- Etoricoxib Impurity 92 (CAS CATO-C4X-108092)
- Methyl 2-(2-(4-chloro-2-methylphenoxy)acetamido)-4-methyl-5-(piperidine-1-carbonyl)thiophene-3-carboxylate (CAS 335410-34-9)
- N-(3-chloro-2-methylphenyl)-2-((5-(2-methoxyphenyl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)acetamide (CAS 482650-60-2)
- Clobetasone Butyrate EP Impurity H (CAS 25122-56-9)
- 5-(Amino(phenyl)methyl)-N-phenylpyridin-2-amine (CAS 1355177-71-7)
- tert-Butyl 4-(4-hydroxyphenyl)piperidine-1-carboxylate (CAS 149377-19-5)
- tert-Butyl cyclopropyl(5-(1-tosylpiperidin-2-yl)pyridin-2-yl)carbamate (CAS 1352540-38-5)
- 5,5-Dimethyl-4,5,6,7-tetrahydro-1H-indazole-3-carboxylic acid (CAS 1342547-91-4)
- (1E)-1-{6-chloroimidazo[2,1-b][1,3]thiazol-5-yl}-N-(3-chlorophenyl)methanimine (CAS 241132-45-6)
- Tert-butyl 4-(1H-indazol-1-yl)piperidine-1-carboxylate (CAS 2386361-81-3)
- 2-(4-Methylpyridin-2-yl)acetic acid hydrochloride (CAS 1609395-40-5)
- Trihexosylceramide (d18:1/12:0) (CAS 474943-80-1)
- 2-methyl-4,5,6,7-tetrahydro-2H-indazole-4-carboxylic acid (CAS 1557768-83-8)
- Insulin B (22-25) (CAS 34367-73-2)
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