2-((5-(4-Chlorophenyl)-4-(p-tolyl)-4H-1,2,4-triazol-3-yl)thio)-1-(3,4-dimethoxyphenyl)ethanone CAS 477332-89-1
| CAS No. | 477332-89-1 |
| Molecular Formula | C25H22ClN3O3S |
| Molecular Weight | 479.98 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2-((5-(4-Chlorophenyl)-4-(p-tolyl)-4H-1,2,4-triazol-3-yl)thio)-1-(3,4-dimethoxyphenyl)ethanone (CAS 477332-89-1) is a high-purity analytical reference standard with the molecular formula C25H22ClN3O3S and a molecular weight of 479.98 g/mol.
2-((5-(4-Chlorophenyl)-4-(p-tolyl)-4H-1,2,4-triazol-3-yl)thio)-1-(3,4-dimethoxyphenyl)ethanone (C25H22ClN3O3S) contains a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2-((5-(4-Chlorophenyl)-4-(p-tolyl)-4H-1,2,4-triazol-3-yl)thio)-1-(3,4-dimethoxyphenyl)ethanone meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C25H22ClN3O3S |
| Molecular Weight | 479.98 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Chlorophenyl Standards
- 2-((5-(4-Chlorophenyl)-4-(p-tolyl)-4H-1,2,4-triazol-3-yl)thio)-1-(2,5-dimethoxyphenyl)ethanone (CAS 477331-66-1)
- 1-(4-Chlorophenyl)-2-((4-methyl-5-(1-methyl-3-phenyl-1H-thieno[2,3-c]pyrazol-5-yl)-4H-1,2,4-triazol-3-yl)thio)ethan-1-one (CAS 478067-21-9)
- (S)-4-((2-(3-Chlorophenyl)-2-hydroxyethyl)amino)-3-(4-methyl-6-morpholino-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one (CAS 468740-43-4)
- Methyl 4-(4-chlorophenyl)-3-(N-(4-(ethoxycarbonyl)phenyl)sulfamoyl)thiophene-2-carboxylate (CAS 1021209-52-8)
- 2-{[(4-chlorophenyl)methyl]sulfanyl}-4-methyl-3-(4-methylbenzenesulfonyl)-6-phenylpyridine (CAS 478245-26-0)
- 5-((4-Chlorophenyl)thio)-1-methyl-3-(trifluoromethyl)-N-(3-(trifluoromethyl)phenyl)-1H-pyrazole-4-carboxamide (CAS 321553-23-5)
- 2-[(4-Chlorophenyl)sulfanyl]-N'-[(1E)-{4-[(3,4-dichlorophenyl)methoxy]phenyl}methylidene]acetohydrazide (CAS 329703-06-2)
- (E)-8-(3-(4-Chlorophenyl)acryloyl)-3-(3,4-dichlorobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one (CAS 1334294-76-6)
Recommended Standards
- Letaxaban (CAS 870262-90-1)
- Desbenzyl N-Acetyl-di-O-acetyl KRP-203 (CAS 951238-24-7)
- N-(4-Chloro-2-methoxy-5-methylphenyl)-2-((5-(pyridin-4-yl)-4-(p-tolyl)-4H-1,2,4-triazol-3-yl)thio)acetamide (CAS 477318-74-4)
- SANT-2 (CAS 329196-48-7)
- N-(3-methylisoxazol-5-yl)acetamide (CAS 68901-49-5)
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- trans-3-{[(tert-butoxy)carbonyl]amino}cyclopentane-1-carboxylic acid (CAS 1245614-69-0)
- Liraglutide Impurity 18 TFA Salt (CAS CATO-C4X-199218)
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