1-(Benzo[d][1,3]dioxol-5-yl)-3-((4-(trifluoromethyl)phenyl)amino)propan-1-one CAS 477334-18-2
| CAS No. | 477334-18-2 |
| Molecular Formula | C17H14F3NO3 |
| Molecular Weight | 337.29 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 1-(Benzo[d][1,3]dioxol-5-yl)-3-((4-(trifluoromethyl)phenyl)amino)propan-1-one is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
1-(Benzo[d][1,3]dioxol-5-yl)-3-((4-(trifluoromethyl)phenyl)amino)propan-1-one (CAS 477334-18-2) is a high-purity analytical reference standard with the molecular formula C17H14F3NO3 and a molecular weight of 337.29 g/mol.
The molecular framework of 1-(Benzo[d][1,3]dioxol-5-yl)-3-((4-(trifluoromethyl)phenyl)amino)propan-1-one (C17H14F3NO3) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 1-(Benzo[d][1,3]dioxol-5-yl)-3-((4-(trifluoromethyl)phenyl)amino)propan-1-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C17H14F3NO3 |
| Molecular Weight | 337.29 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Benzo Standards
- 7-(Benzo[d][1,3]dioxole-5-carbonyl)-[1,3]dioxolo[4,5-g]quinolin-8(5H)-one (CAS 1326806-77-2)
- Benzo[d]thiazol-2-ylmethyl 2-oxo-2H-chromene-3-carboxylate (CAS 391867-20-2)
- 77784-22-6 5H-Benzo(g)-1,3-benzodioxolo(6,5,4-de)quinoline, 6,7-dihydro-9,10-dimethoxy-7-methyl- Dehydrocrebanine CCRIS 3812 6,7-Dihydro-9,10-dimethoxy-7-methyl-5H-benzo(g)-1,3-benzodioxolo(6,5,4-de)quinoline (CAS 77784-22-6)
- 2-(1H-benzo[d][1,2,3]triazol-1-yl)-1-cyclohexyl-2-phenoxyethan-1-ol (CAS 162107-46-2)
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- (4-(Benzo[d]thiazol-2-yl)piperazin-1-yl)(p-tolyl)methanone (CAS 309276-74-2)
- 1-(4-(Benzo[d]thiazol-2-yl)piperazin-1-yl)-2-phenylethan-1-one (CAS 681158-23-6)
- 4-(Benzo[b]thiophen-3-ylmethoxy)-3-butyl-3H-imidazo[4,5-c]pyridine (CAS 87035-27-6)
Recommended Standards
- (3-(11-Mercaptoundecanamido)phenyl)boronic acid (CAS 260248-92-8)
- 2-(Methylsulfinyl)-8-nitro-6-(trifluoromethyl)-4H-thiochromen-4-one (CAS 2648707-88-2)
- (2R,3R,3AS,5S,7R,7aR)-2-(6-amino-9H-purin-9-yl)-3,7-dihydroxyhexahydro-2H-furo[3,2-b]pyran-5-carboxylic acid (CAS 60825-13-0)
- 2,6-dimethoxy-3-(trimethylsilyl)pyridine-5-boronic acid pinacol ester (CAS 2121513-69-5)
- 4-((Cyclopropyl(methyl)amino)methyl)benzoic acid (CAS 1094857-03-0)
- 4-(2,5-Dimethoxyphenyl)-5-methyl-4H-1,2,4-triazole-3-thiol (CAS 667407-74-1)
- 1-(4-Fluoro-2-(trifluoromethyl)phenyl)-N,N-dimethylpiperidin-4-amine (CAS 1707605-08-0)
- 2-{3-[(3-chlorophenyl)methoxy]phenyl}acetic acid (CAS 1258651-59-0)
- 5-Methyl-3-(trifluoromethyl)aniline (CAS 96100-12-8)
- 1-(Tert-butoxycarbonyl)-5,5-dimethylpiperidine-3-carboxylic acid (CAS 1781347-99-6)
- Ethyl 6-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}-4-hydroxyquinoline-3-carboxylate (CAS 339099-91-1)
- (4AS,7aS)-methyl 1-((tert-butyldimethylsilyl)oxy)-7-hydroxy-7-methyl-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-4-carboxylate (CAS 1951430-56-0)
- 4-(4-(Trifluoromethyl)benzyl)piperidine (CAS 192990-03-7)
- Semaglutide impurity 227 (CAS CATO-C4X-2226227)
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