1-Methyl-N'-(thiophene-2-carbonyl)-3-(trifluoromethyl)-1H-pyrazole-4-carbohydrazide CAS 477762-33-7
| CAS No. | 477762-33-7 |
| Molecular Formula | C11H9F3N4O2S |
| Molecular Weight | 318.27 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO supplies 1-Methyl-N'-(thiophene-2-carbonyl)-3-(trifluoromethyl)-1H-pyrazole-4-carbohydrazide (CAS 477762-33-7), a certified reference material (molecular formula C11H9F3N4O2S, MW 318.27 g/mol) for analytical method development and quality control.
The molecular framework of 1-Methyl-N'-(thiophene-2-carbonyl)-3-(trifluoromethyl)-1H-pyrazole-4-carbohydrazide (C11H9F3N4O2S) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a certified reference material (CRM), 1-Methyl-N'-(thiophene-2-carbonyl)-3-(trifluoromethyl)-1H-pyrazole-4-carbohydrazide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H9F3N4O2S |
| Molecular Weight | 318.27 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
| Sulfur Atoms | 1 |
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