3-(Thiophen-2-yl)-N-[4-(trifluoromethoxy)phenyl]-6-(trifluoromethyl)thieno[3,2-b]pyridine-2-carboxamide CAS 477845-16-2
| CAS No. | 477845-16-2 |
| Molecular Formula | C20H10F6N2O2S2 |
| Molecular Weight | 488.43 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 3-(Thiophen-2-yl)-N-[4-(trifluoromethoxy)phenyl]-6-(trifluoromethyl)thieno[3,2-b]pyridine-2-carboxamide.
3-(Thiophen-2-yl)-N-[4-(trifluoromethoxy)phenyl]-6-(trifluoromethyl)thieno[3,2-b]pyridine-2-carboxamide (CAS 477845-16-2) is a high-purity analytical reference standard with the molecular formula C20H10F6N2O2S2 and a molecular weight of 488.43 g/mol.
Structurally, 3-(Thiophen-2-yl)-N-[4-(trifluoromethoxy)phenyl]-6-(trifluoromethyl)thieno[3,2-b]pyridine-2-carboxamide (C20H10F6N2O2S2) contains a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 14.0, corresponding to approximately 14 ring(s) or double-bond equivalent(s). With a molecular weight of 488.43 g/mol, it falls into the moderately-high-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 3-(Thiophen-2-yl)-N-[4-(trifluoromethoxy)phenyl]-6-(trifluoromethyl)thieno[3,2-b]pyridine-2-carboxamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C20H10F6N2O2S2 |
| Molecular Weight | 488.43 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 2 |
Related Thiophen Standards
- 2-((4-Ethyl-5-(thiophen-2-yl)-4H-1,2,4-triazol-3-yl)thio)-N-(4-(6-methylbenzo[d]thiazol-2-yl)phenyl)acetamide (CAS 566144-84-1)
- N-(thiophen-2-ylmethyl)-2-(2-((1-tosyl-1H-indol-4-yl)oxy)ethoxy)ethan-1-amine (CAS 439094-58-3)
- 4,4'-(Thiophen-2-ylmethylene)bis(1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one) (CAS 2608-62-0)
- 2-((4-Ethyl-5-(thiophen-2-yl)-4H-1,2,4-triazol-3-yl)thio)-N-(2-methoxydibenzo[b,d]furan-3-yl)acetamide (CAS 577986-57-3)
- 4-Phenyl-5-(3-(thiophen-2-yl)-6-(trifluoromethyl)thieno[3,2-b]pyridin-2-yl)-2,4-dihydro-3H-1,2,4-triazole-3-thione (CAS 478048-40-7)
- 3-Methyl-5-((4-(2-(thiophen-3-yl)acetyl)piperazin-1-yl)sulfonyl)thiophene-2,4-dicarboxylic acid (CAS 920610-77-1)
- 2-thiophen-2-yl-5-[5-[5-(5-thiophen-2-ylthiophen-2-yl)thiophen-2-yl]thiophen-2-yl]thiophene 88493-55-4 (CAS 88493-55-4)
- 4-[4-(Thiophen-2-yl)pyrimidin-2-yl]phenyl 4-acetamidobenzene-1-sulfonate (CAS 477862-27-4)
Recommended Standards
- (R)-2-(1-methyl-2-tritylisoindolin-5-yl)-1,3,6,2-dioxazaborocane (CAS 223595-20-8)
- 5-(2,2-Dimethyl-1,3-dioxolan-4-yl)-3,4-bis[2-(4-fluorophenyl)-2-oxoethoxy]-2,5-dihydrofuran-2-one (CAS 866151-25-9)
- N,N-Bis(trifluoroacetyl)-L-homocystine Dimethyl Ester (CAS 84355-09-9)
- N-((1'-benzyl-4',5'-dimethyl-1'H-[1,2'-bipyrrol]-3'-yl)methyl)-3,5-dichlorobenzenesulfonamide (CAS 478077-23-5)
- 1-benzylpyrrolidine-2,5-dicarboxylic acid (CAS 433933-93-8)
- Ethyl 1-Boc-5-methoxypyrrolidine-2-carboxylate (CAS 183506-26-5)
- 2-Cyclopropyl-3-(4-methyl-1h-pyrazol-1-yl)-2-(methylamino)propanamide (CAS 1340299-84-4)
- 4-(Cyclopropylamino)-2-(methylthio)pyrimidine-5-carboxylic acid (CAS 1015856-32-2)
- Lithium benzo[d]thiazole-2-carboxylate (CAS 1359706-28-7)
- 2-Bromo-5-(4-methoxyphenoxy)-1,3,4-thiadiazole (CAS 946884-40-8)
- Methyl 7-fluoroquinoline-8-carboxylate (CAS 1541859-31-7)
- 2-(4-Bromothiophen-2-yl)-2-(((tetrahydrofuran-2-yl)methyl)amino)acetic acid (CAS 1291008-67-7)
- 1-((Cyclohex-3-en-1-ylmethyl)amino)-2-methylpropan-2-ol (CAS 1247455-73-7)
- Peptide 6A (H-6905.0005) (CAS 73549-32-3)
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