N-(3,5-Dichlorophenyl)-N-[(dimethylamino)methylene]thiourea CAS 477852-00-9
| CAS No. | 477852-00-9 |
| Molecular Formula | C10H11Cl2N3S |
| Molecular Weight | 276.19 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
N-(3,5-Dichlorophenyl)-N-[(dimethylamino)methylene]thiourea (CAS 477852-00-9), molecular formula C10H11Cl2N3S and molecular weight 276.19 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a nitrogen-containing heterocyclic scaffold, a nitrile group, sulfur-containing functionality, chlorine substitution, N-(3,5-Dichlorophenyl)-N-[(dimethylamino)methylene]thiourea is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 276.19 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H11Cl2N3S |
| Molecular Weight | 276.19 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related N Standards
- N-(3,4-Dichlorophenyl)-N-[(dimethylamino)methylene]thiourea (CAS 99590-57-5)
- Ethyl 2-(3,4-dichlorophenyl)-2-(methylamino)propanoate (CAS 1184272-89-6)
- 2-(3,5-Dichlorophenyl)-2-(diethylamino)acetic acid (CAS 1218081-04-9)
- Ethyl 2-(3,5-dichlorophenyl)-2-(ethylamino)acetate (CAS 1218548-99-2)
- 2-(2,4-Dichlorophenyl)-N-(4-hydroxybutan-2-yl)acetamide (CAS 1423678-93-6)
- 2-(2,4-Dichlorophenyl)-1-methyl-1H-indole (CAS 905808-86-8)
- 4-(2,4-Dichlorophenyl)thiomorpholine-3,5-dione (CAS 338409-82-8)
- 4-(2,6-Dichlorophenyl)thiomorpholine-3,5-dione (CAS 338421-38-8)
Recommended Standards
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- 4,4,4-Trifluoro-1-(thiophen-2-yl)-3-(trifluoromethyl)but-2-en-1-ol (CAS 100482-55-1)
- 5-Bromo-N-(tert-pentyl)thiophene-2-carboxamide (CAS 515860-51-2)
- (S)-4-Methyl-3-methylenepyrrolidin-2-one (CAS 2796968-96-0)
- Cyclopropyl(6-methylpyridin-2-yl)methanamine (CAS 1211162-77-4)
- Adefovir Trimer (CAS CATO-C4X-115227)
- 2-((5-(Pyridin-2-yl)-1,3,4-oxadiazol-2-yl)thio)propanamide (CAS 604739-85-7)
- 1-(3-Fluorophenyl)butan-1-amine hydrochloride (CAS 1864074-37-2)
- 2-Propenoic acid, 2-cyano-3-[(4-methoxyphenyl)amino]-, ethyl ester (CAS 67964-19-6)
- Tegoprazan Impurity 75 (CAS CATO-C4X-229775)
- 1-(3-Chlorobenzyl)imidazolidine-2,4,5-trione (CAS 341966-51-6)
- Ethyl 4-formyl-1-methyl-1H-pyrazole-3-carboxylate (CAS 1594890-30-8)
- Semaglutide impurity 84 (CAS CATO-C4X-222684)
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