2-(4-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}phenyl)-4-(2,4-dichlorophenyl)pyrimidine CAS 477856-46-5
| CAS No. | 477856-46-5 |
| Molecular Formula | C22H11Cl3F3N3O |
| Molecular Weight | 496.70 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
CATO supplies 2-(4-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}phenyl)-4-(2,4-dichlorophenyl)pyrimidine (CAS 477856-46-5), a certified reference material (molecular formula C22H11Cl3F3N3O, MW 496.70 g/mol) for analytical method development and quality control.
The molecular framework of 2-(4-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}phenyl)-4-(2,4-dichlorophenyl)pyrimidine (C22H11Cl3F3N3O) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
CATO manufactures 2-(4-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}phenyl)-4-(2,4-dichlorophenyl)pyrimidine under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C22H11Cl3F3N3O |
| Molecular Weight | 496.70 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related chloro Standards
- (5Z)-3-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-4-(4-chlorophenyl)-5-[(4-chlorophenyl)methylidene]-2,5-dihydrofuran-2-one (CAS 320420-50-6)
- Benzyl 4-(8-chloro-1-iodoimidazo[1,5-a]pyrazin-3-yl)piperidine-1-carboxylate (CAS 936901-82-5)
- 4-Chloro-5-phenyl-3-(1,1,2,2,3,3,4,4,5,5,6,6,6-tridecafluorohexyl)-1h-pyrazole (CAS 1029636-11-0)
- 3-(6-Chloro-1,1,2,2,3,3,4,4,5,5,6,6-dodecafluorohexyl)-3,4,4-trifluoro-1,2-oxathietane 2,2-dioxide (CAS 1244856-02-7)
- 2-(4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)ethyl (3-(trifluoromethyl)phenyl)carbamate (CAS 338748-57-5)
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- 2-{[5-chloro-1-(4-methoxyphenyl)-6-oxo-1,6-dihydropyridazin-4-yl](methyl)amino}ethyl N-[3-(trifluoromethyl)phenyl]carbamate (CAS 477867-36-0)
Recommended Standards
- 2-[3-(5-Bromo-6-methoxynaphthalen-2-yl)-4-methyl-1H-pyrazol-1-yl]-3-chloro-5-(trifluoromethyl)pyridine (CAS 318239-45-1)
- N1,N1-Bis(3,5-di-tert-butyl-2-hydroxyphenyl)oxalamide (CAS 36931-29-0)
- 3-O-Acetyl 9,11-dehydro β-boswellic acid (CAS 122651-20-1)
- N1,N1-Bis(4-(octyloxy)phenyl)oxalamide (CAS 19532-76-4)
- N-Methoxy-2-nitrobenzenesulfonamide (CAS 1061696-67-0)
- 4-Chloro-2-(2-chloro-6-fluorophenyl)-thiazolo[5,4-c]pyridine (CAS 1242249-93-9)
- 2-(Benzo[d]thiazol-2-yl)malonaldehyde (CAS 40070-83-5)
- Fmoc-D-Phe(4-Cl)-OH (CAS 142994-19-2)
- (3AR,7aS)-6-methoxy-2-methyl-3a,7a-dihydro-3H-indole (CAS 353247-97-9)
- 2-(Benzo[d][1,3]dioxol-5-yl)-7-methoxy-1'-propyl-1,10b-dihydrospiro[benzo[e]pyrazolo[1,5-c][1,3]oxazine-5,4'-piperidine] (CAS 840472-07-3)
- Methyl 6-hydroxy-2-methoxy-7,8-dihydroquinoline-5-carboxylate (CAS 120686-00-2)
- 4-Nitrobenzyl 2-((1R,5R)-3-benzyl-7-oxo-4-thia-2,6-Diazabicyclo[3.2.0]hept-2-en-6-yl)-3-methylbut-2-enoate (CAS 192049-49-3)
- 5-(Thiophen-2-yl)-1h-pyrrole-2-carbaldehyde (CAS 72078-45-6)
- Acetyl Hexapeptide-39 (CAS 1382088-38-1)
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