4-[4-(4-Methoxyphenyl)pyrimidin-2-yl]phenyl 3,4-dimethoxybenzene-1-sulfonate CAS 477857-11-7
| CAS No. | 477857-11-7 |
| Molecular Formula | C25H22N2O6S |
| Molecular Weight | 478.52 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
4-[4-(4-Methoxyphenyl)pyrimidin-2-yl]phenyl 3,4-dimethoxybenzene-1-sulfonate (CAS 477857-11-7) is a high-purity analytical reference standard with the molecular formula C25H22N2O6S and a molecular weight of 478.52 g/mol.
The molecular framework of 4-[4-(4-Methoxyphenyl)pyrimidin-2-yl]phenyl 3,4-dimethoxybenzene-1-sulfonate (C25H22N2O6S) is characterized by a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C25H22N2O6S |
| Molecular Weight | 478.52 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Methoxyphenyl Standards
- 2-(4-Methoxyphenyl)-4-oxo-4H-chromen-3-yl 2,3,4,5,6-pentamethylbenzene-1-sulfonate (CAS 301193-63-5)
- 4-(((3-(4-Methoxyphenyl)-4-oxo-3,4,5,6,7,8-hexahydrobenzo[4,5]thieno[2,3-d]pyrimidin-2-yl)thio)methyl)benzoic acid (CAS 477330-71-5)
- Ethyl 5-(4-methoxyphenyl)-7-methyl-2-(4-nitrobenzylidene)-3-oxo-3,5-dihydro-2H-thiazolo[3,2-a]pyrimidine-6-carboxylate (CAS 300723-22-2)
- 2'-((2-(4-Methoxyphenyl)acetamido)methyl)-N-(2-(pyridin-3-yl)ethyl)-[1,1'-biphenyl]-2-carboxamide (CAS 498577-53-0)
- 3-(4-Methoxyphenyl)-2-((4-nitrobenzyl)thio)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one (CAS 477331-59-2)
- 5-[4-(2-Methoxyphenyl)piperazin-1-yl]-1-(4-methylbenzenesulfonyl)-4,5,6,7-tetrahydro-1H-indol-4-one (CAS 439094-50-5)
- 2-(4-Methoxyphenyl)-4-oxo-4H-chromen-3-yl 2,4-dichlorobenzenesulfonate (CAS 301193-70-4)
- 2-(4-Methoxyphenyl)-4-oxo-4H-chromen-3-yl 2,5-dichlorobenzene-1-sulfonate (CAS 298215-72-2)
Recommended Standards
- 3-(N-(Benzo[d][1,3]dioxol-5-yl)sulfamoyl)-N-(2-(2-methyl-1H-benzo[d]imidazol-1-yl)ethyl)benzamide (CAS 920882-44-6)
- 5-[4-(2-{[6-(4-Methoxyphenoxy)pyrimidin-4-yl]methylamino}ethoxy)benzylidene]thiazolidine-2,4-dione, 95% (CAS 607722-95-2)
- 2-(3-((N-(4-(1H-pyrazol-1-yl)benzyl)pyridine-3-sulfonamido)methyl)phenoxy)acetic acid (CAS 752187-80-7)
- Methyl 3-nitro-4-{4-[(5Z)-4-oxo-5-[(2E)-3-phenylprop-2-en-1-ylidene]-4,5-dihydro-1,3-thiazol-2-yl]piperazin-1-yl}benzoate (CAS 860651-21-4)
- (4-methoxyphenyl)[4-(trifluoromethyl)phenyl]methanamine hydrochloride (CAS 1443980-52-6)
- (4S)-(3',4'-Dichlorophenyl)-3,4-dihydro-1,2-epoxy-1-O-triethylsilyl-1-naphthol (CAS 1217528-57-8)
- 6-Chloro-3-(p-tolyl)-2-(p-tolylethynyl)quinoxaline (CAS 1319039-36-5)
- 2-cyano-3-(dimethylamino)-N-[(methoxyimino)methyl]acrylamide (CAS 303995-04-2)
- 2-Bromo-1-methoxy-3,4-dimethylbenzene (CAS 725227-56-5)
- (Z)-4-Hydroxytamoxifen (CAS 68047-06-3)
- 7-(Benzyloxy)quinoline (CAS 131802-60-3)
- tert-Butyl 2-propylpiperazine-1-carboxylate hydrochloride (CAS 1202993-25-6)
- 3,6-Dimethylheptanoic acid (CAS 44980-98-5)
- Semaglutide impurity 74 (CAS CATO-C4X-222674)
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