N-Methyl-2,5-bis(2,2,2-trifluoroethoxy)benzamide CAS 477863-91-5

Description

N-Methyl-2,5-bis(2,2,2-trifluoroethoxy)benzamide (CAS 477863-91-5) is a high-purity analytical reference standard with the molecular formula C12H11F6NO3 and a molecular weight of 331.21 g/mol.

N-Methyl-2,5-bis(2,2,2-trifluoroethoxy)benzamide (C12H11F6NO3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

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