Ethyl 2-[3-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]-2,6-dioxo-3,6-dihydro-1(2H)-pyrimidinyl]acetate CAS 477864-62-3
| CAS No. | 477864-62-3 |
| Molecular Formula | C14H11ClF3N3O4 |
| Molecular Weight | 377.70 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Ethyl 2-[3-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]-2,6-dioxo-3,6-dihydro-1(2H)-pyrimidinyl]acetate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Ethyl 2-[3-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]-2,6-dioxo-3,6-dihydro-1(2H)-pyrimidinyl]acetate (CAS 477864-62-3) is a high-purity analytical reference standard with the molecular formula C14H11ClF3N3O4 and a molecular weight of 377.70 g/mol.
The molecular framework of Ethyl 2-[3-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]-2,6-dioxo-3,6-dihydro-1(2H)-pyrimidinyl]acetate (C14H11ClF3N3O4) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C14H11ClF3N3O4 |
| Molecular Weight | 377.70 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related Ethyl Standards
- Ethyl 4-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)carbamoyl)-5-methylisoxazole-3-carboxylate (CAS 338397-35-6)
- 3-(4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-1,1,1-trifluoropropan-2-ol (CAS 477858-21-2)
- 5-({2-[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]hydrazino}methylene)-1,3-dimethyl-2,4,6(1H,3H,5H)-pyrimidinetrione (CAS 338978-25-9)
- ethyl 2-chloro-3,3,3-trifluoro-2-{[3-(trifluoromethyl)benzoyl]amino}propanoate (CAS 680214-27-1)
- Ethyl 4-chloro-2-((2,4-dichlorobenzyl)thio)pyrimidine-5-carboxylate (CAS 6944-75-8)
- 3-Chloro-4-[2,6-dinitro-4-(trifluoromethyl)phenoxy]aniline (CAS 338412-96-7)
- 2-[(4-chloro-3-fluoroanilino)methylidene]-4,4,4-trifluoro-1-(2-thienyl)butane-1,3-dione (CAS 649578-89-2)
- 2-(4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine-1-carbonyl)cyclopropane-1-carboxylic acid (CAS 1023559-02-5)
Recommended Standards
- Rel-(1R,3s,5S)-3-(4-(5-bromo-2-chlorobenzyl)phenoxy)bicyclo[3.1.0]hexane (CAS 1800112-27-9)
- 2-(4-(3-(4-Bromo-2-chlorophenoxy)propyl)piperazin-1-yl)ethanol (CAS 1704074-16-7)
- 4-Bromo-2-((4-chlorophenyl)thio)-N,N-dimethylthiazole-5-carboxamide (CAS 1000576-42-0)
- 6-[(4-Bromophenyl)sulfanyl]-4-chloro-3-phenylpyridazine (CAS 477872-30-3)
- (E)-N-(5-chloro-2-methylphenyl)-3-(furan-2-yl)acrylamide (CAS 423150-34-9)
- Quinuclidine-2-carboxylic acid hydrochloride (CAS 52601-23-7)
- 1-[4-(tert-Butyl)phenyl]cyclobutanemethanamine Hydrochloride (CAS 1235440-78-4)
- 2,3-Dichloro-4-fluorobenzonitrile (CAS 908123-82-0)
- Hexahydroimidazo[1,5-a]pyridine-3(2H)-thione (CAS 33852-28-7)
- Ledipasvir Impurity 4 (CAS CATO-C4X-33134)
- 4-(3-aminopropanamido)-2-chlorobenzamide hydrochloride (CAS 1864053-55-3)
- 2-Azido-3,4,7,8-tetramethyl-3H-imidazo[4,5-f]quinoxaline-d3 (CAS 1215749-04-4)
- 5-(3-Chloro-2-methylphenyl)-5-oxopentanoic acid (CAS 1417462-41-9)
- (Asp28)-Exenatide trifluoroacetate salt (CAS 1678417-24-7)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com