3-Chloro-N-(3-cyano-4-((3-(trifluoromethyl)phenyl)sulfonyl)phenyl)benzamide CAS 477866-92-5
| CAS No. | 477866-92-5 |
| Molecular Formula | C21H12ClF3N2O3S |
| Molecular Weight | 464.84 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
3-Chloro-N-(3-cyano-4-((3-(trifluoromethyl)phenyl)sulfonyl)phenyl)benzamide (CAS 477866-92-5), molecular formula C21H12ClF3N2O3S and molecular weight 464.84 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 3-Chloro-N-(3-cyano-4-((3-(trifluoromethyl)phenyl)sulfonyl)phenyl)benzamide (C21H12ClF3N2O3S) is characterized by a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 3-Chloro-N-(3-cyano-4-((3-(trifluoromethyl)phenyl)sulfonyl)phenyl)benzamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H12ClF3N2O3S |
| Molecular Weight | 464.84 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Chloro Standards
- 3-(4-((2-Chloro-4-nitrophenoxy)methyl)benzamido)benzene-1-sulfonyl fluoride (CAS 30880-66-1)
- 4-(4-((2-Chloro-4-nitrophenoxy)methyl)benzamido)benzene-1-sulfonyl fluoride (CAS 30880-67-2)
- Methyl 2-(5-chloro-2-oxo-1-(4-(trifluoromethyl)benzyl)-1,2-dihydropyridine-3-carboxamido)benzoate (CAS 242797-21-3)
- (2E)-3-(2-Chloro-5-nitrophenyl)-2-{4-[2-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)ethyl]-1,3-thiazol-2-yl}prop-2-enenitrile (CAS 866050-90-0)
- 4-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}-N-(2,4-difluorophenyl)benzene-1-sulfonamide (CAS 338775-42-1)
- 2-(2-(3-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl)ethyl)isoindoline-1,3-dione (CAS 251310-59-5)
- 4-Chloro-N,N-bis(4-methoxybenzyl)-3,6-dimethyl-5-(trifluoromethyl)pyridin-2-amine (CAS 2852767-64-5)
- 6-Chloro-N,N-bis(4-methoxybenzyl)-4-methyl-5-(2,2,2-trifluoroethyl)pyridin-2-amine (CAS 2852767-00-9)
Recommended Standards
- (2Z)-2-(4-Chlorobenzenesulfonyl)-3-(4-{[5-(trifluoromethyl)pyridin-2-yl]oxy}phenyl)prop-2-enenitrile (CAS 1025270-09-0)
- N-(4-((4-chlorophenyl)sulfonyl)-3-cyanophenyl)-3-(trifluoromethyl)benzamide (CAS 306980-65-4)
- ((2R,4S)-4-amino-2-(4-chlorobenzyl)piperidin-1-yl)(3,5-bis(trifluoromethyl)phenyl)methanone (CAS 177707-22-1)
- 5-(Chloromethyl)-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-3',6'-diyl diacetate (CAS 136832-63-8)
- 4-Amino-1-(2-chlorophenyl)pyrrolidin-2-one hydrochloride (CAS 1177342-40-3)
- 5-Bromo-1H-pyrrole-2-carbaldehyde (CAS 931-34-0)
- N-Hydroxy-4-(thiazol-2-yl)benzimidamide (CAS 2197064-39-2)
- 5-Iodo-1-methylpiperidin-2-one (CAS 1393100-26-9)
- tert-butyl N-[(1S,3S)-3-hydroxycyclopentyl]-N-methylcarbamate (CAS 2165760-01-8)
- 2-Ethyl-3-methylbenzofuran (CAS 80079-25-0)
- Fluazinam Impurity 1 (CAS 169327-87-1)
- Ethyl 4-((2-hydroxyethyl)amino)-6-methoxyquinoline-3-carboxylate (CAS 370841-36-4)
- Methyl 2-(benzylamino)-5-pyrimidinecarboxylate (CAS 927803-45-0)
- Neuropeptide Y (porcine) trifluoroacetate salt (CAS 83589-17-7)
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