N-{2-[({5-oxo-2H,3H,5H-[1,3]thiazolo[2,3-b]quinazolin-3-yl}methyl)sulfanyl]phenyl}-3-(trifluoromethyl)benzamide CAS 477868-86-3
| CAS No. | 477868-86-3 |
| Molecular Formula | C25H18F3N3O2S2 |
| Molecular Weight | 513.55 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), N-{2-[({5-oxo-2H,3H,5H-[1,3]thiazolo[2,3-b]quinazolin-3-yl}methyl)sulfanyl]phenyl}-3-(trifluoromethyl)benzamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
N-{2-[({5-oxo-2H,3H,5H-[1,3]thiazolo[2,3-b]quinazolin-3-yl}methyl)sulfanyl]phenyl}-3-(trifluoromethyl)benzamide (CAS 477868-86-3), molecular formula C25H18F3N3O2S2 and molecular weight 513.55 g/mol, is a CATO reference standard with documented purity and traceability.
N-{2-[({5-oxo-2H,3H,5H-[1,3]thiazolo[2,3-b]quinazolin-3-yl}methyl)sulfanyl]phenyl}-3-(trifluoromethyl)benzamide (C25H18F3N3O2S2) contains a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C25H18F3N3O2S2 |
| Molecular Weight | 513.55 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 17.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 2 |
Recommended Standards
- Ertugliflozin impurity 56 (CAS CATO-C4X-301156)
- N-Acetylpurinomycin (CAS 22852-13-7)
- 2-[(5-Fluoresceinyl)aminocarbonyl]ethyl Methanethiosulfonate (CAS 887355-30-8)
- 14-(4-Nitrophenoxy)-3,6,9,12-tetraoxatetradecyl 4-methylbenzenesulfonate (CAS 168784-49-4)
- 4-Amino-7-fluoro-N-(3,4,5-trimethoxyphenyl)cinnoline-3-carboxamide (CAS 187231-60-3)
- (6-(tert-Butoxy)-4-cyclopropoxypyridin-2-yl)methanamine (CAS 1243329-01-2)
- Isopropylphenylglyoxylate (CAS 31197-66-7)
- 4-bromo-2-fluoro-3-methylpyridine (CAS 128071-79-4)
- 2-Amino-6-bromobenzamide (CAS 1108790-90-4)
- Methyl 5-methyl-3-(2,2,2-trifluoroacetamido)thiophene-2-carboxylate (CAS 1352723-61-5)
- 199450-10-7 Copper(1+) (~13~C,~15~N)cyanide DTXSID00746496 (CAS 199450-10-7)
- (1s,2r)-2-Methylcyclohexan-1-amine (CAS 79389-36-9)
- 6-Bromo-3-methylquinoline-5,8-dione (CAS 756899-09-9)
- D-Ala21-Tirzepatide (CAS CATO-CPTD788913)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com