1-(2-(1H-indol-3-yl)ethyl)-3-(2-chloro-6-fluorobenzyl)-4-hydroxypyridin-2(1H)-one CAS 477869-79-7
| CAS No. | 477869-79-7 |
| Molecular Formula | C22H18ClFN2O2 |
| Molecular Weight | 396.84 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 1-(2-(1H-indol-3-yl)ethyl)-3-(2-chloro-6-fluorobenzyl)-4-hydroxypyridin-2(1H)-one.
CATO supplies 1-(2-(1H-indol-3-yl)ethyl)-3-(2-chloro-6-fluorobenzyl)-4-hydroxypyridin-2(1H)-one (CAS 477869-79-7), a certified reference material (molecular formula C22H18ClFN2O2, MW 396.84 g/mol) for analytical method development and quality control.
1-(2-(1H-indol-3-yl)ethyl)-3-(2-chloro-6-fluorobenzyl)-4-hydroxypyridin-2(1H)-one (C22H18ClFN2O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H18ClFN2O2 |
| Molecular Weight | 396.84 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related H Standards
- 2-((1H-Indol-3-yl)methyl)-6-bromo-3-hydroxyquinoline-4-carboxylic acid (CAS 924634-80-0)
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- 1380572-63-3 5-[2-(1H-Indol-3-yl)-2-oxo-ethylidene]-3-(4-methoxy-phenyl)-2-thioxo-thiazolidin-4-one (CAS 1380572-63-3)
- (4-(3-(1H-Indol-3-yl)propanoyl)piperazine-1-carbonyl)-L-valine (CAS 1014103-99-1)
- 3-(1H-Indol-3-yl)-6-iodo-2-methylquinazolin-4(3H)-one (CAS 655250-50-3)
- (1H-Indol-5-yl)(3-((3-(thiophen-3-yl)-1,2,4-oxadiazol-5-yl)methyl)piperidin-1-yl)methanone (CAS 1706230-50-3)
- 2-(2-(1H-indol-3-yl)acetyl)-N-(4-(trifluoromethoxy)phenyl)hydrazine-1-carboxamide (CAS 1024068-67-4)
Recommended Standards
- Darolutamide Impurity 30 (CAS CATO-C4X-310630)
- 4-[(2-Chloro-6-fluorophenyl)methoxy]-N'-[(1E)-(4-methylphenyl)methylidene]benzohydrazide (CAS 303987-26-0)
- Darolutamide Impurity 27 (CAS 1297538-27-2)
- (R)-4-(3-(2-Amino-5-chloropyrimidin-4-yl)imidazo[1,2-a]pyridin-6-yl)-2-(thiazol-2-yl)but-3-yn-2-ol (CAS 1202764-63-3)
- 3-(Methoxymethyl)-5-methyl-1H-pyrazole (CAS 37599-51-2)
- (2R,5S)-1-Boc-4-benzyl-2,5-dimethylpiperazine (CAS 431062-00-9)
- n-[4-(chloromethyl)-1,3-thiazol-2-yl]-n-methylacetamide (CAS 37060-75-6)
- 6-(4-Bromophenyl)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one (CAS 33298-00-9)
- 6-Bromo-1-(3-fluorobenzyl)-1H-pyrrolo[3,2-b]pyridine (CAS 1627971-81-6)
- Ethyl 5-methyl-3-(3-nitrophenyl)isoxazole-4-carboxylate (CAS 93187-48-5)
- 2,2'-(1,4-Phenylene)bis(benzo[d]oxazol-5-amine) (CAS 13752-53-9)
- 3-(4-Bromophenyl)-6,8-dichloro-2-methyl-3,4-dihydroquinazolin-4-one (CAS 299928-87-3)
- Isopropyl 2,6-dichloroisonicotinate (CAS 99055-12-6)
- Semaglutide impurity 194 (CAS CATO-C4X-2226194)
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