Ethyl 2-(4-fluorophenyl)-1-indolizinecarboxylate CAS 477870-69-2
| CAS No. | 477870-69-2 |
| Molecular Formula | C17H14FNO2 |
| Molecular Weight | 283.30 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
Ethyl 2-(4-fluorophenyl)-1-indolizinecarboxylate (CAS 477870-69-2) is a high-purity analytical reference standard with the molecular formula C17H14FNO2 and a molecular weight of 283.30 g/mol.
The molecular framework of Ethyl 2-(4-fluorophenyl)-1-indolizinecarboxylate (C17H14FNO2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C17H14FNO2 |
| Molecular Weight | 283.30 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
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Recommended Standards
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- 2-((1-Benzoyl-5-phenyl-1H-imidazol-2-yl)thio)-N-(2,6-dimethylphenyl)acetamide (CAS 332101-53-8)
- 2-Propylthiazole (CAS 17626-75-4)
- Diethyl (2-aminoethyl)phosphonate hydrochloride (CAS 1089328-92-6)
- Ipratropium Bromide EP Impurity D (CAS 492-38-6)
- 2-(1-(Tert-butoxycarbonyl)-3-(ethylamino)azetidin-3-yl)acetic acid (CAS 1697047-80-5)
- 3-(4-methoxyphenyl)-1-(1H-pyrrol-1-yl)propan-1-one (CAS 448905-82-6)
- 4-((Benzyloxy)methyl)-1H-indole-3-carbaldehyde (CAS 887575-83-9)
- N-(3-Amino[1,1-biphenyl]-4-yl)-carbamic Acid tert-Butyl Ester (CAS 335255-33-9)
- {1-[(1-methyl-1h-pyrazol-4-yl)methyl]piperidin-3-yl}methanamine (CAS 1006483-95-9)
- Neuropeptide S (rat) (CAS 412938-75-1)
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