(E)-[1-(2,4-Dimethyl-1,3-thiazol-5-yl)ethylidene]amino thiophene-2-carboxylate CAS 477872-43-8

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including (E)-[1-(2,4-Dimethyl-1,3-thiazol-5-yl)ethylidene]amino thiophene-2-carboxylate.

(E)-[1-(2,4-Dimethyl-1,3-thiazol-5-yl)ethylidene]amino thiophene-2-carboxylate (CAS 477872-43-8), molecular formula C12H12N2O2S2 and molecular weight 280.37 g/mol, is a CATO reference standard with documented purity and traceability.

(E)-[1-(2,4-Dimethyl-1,3-thiazol-5-yl)ethylidene]amino thiophene-2-carboxylate (C12H12N2O2S2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage. It is notably hygroscopic, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

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