Latanoprost EP Impurity J CAS 477884-78-9
| CAS No. | 477884-78-9 |
| Molecular Formula | C44H82O5Si3 |
| Molecular Weight | 775.38 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Latanoprost EP Impurity J is closely related to a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Latanoprost EP Impurity J (CAS 477884-78-9) is a certified pharmaceutical impurity reference standard with the molecular formula C44H82O5Si3 and a molecular weight of 775.38 g/mol.
Structurally, Latanoprost EP Impurity J (C44H82O5Si3) contains a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 4.0, corresponding to approximately 4 ring(s) or double-bond equivalent(s). With a molecular weight of 775.38 g/mol, it falls into the high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C44H82O5Si3 |
| Molecular Weight | 775.38 g/mol |
| Purity | >95% |
| Storage | Store at room temperature, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
Related Latanoprost Standards
- Latanoprost Enol Impurity (CAS 41639-73-0)
- Latanoprost Impurity 25 (CAS CATO-C4X-194125)
- Latanoprost EP Impurity C (CAS CATO-C4X-194117)
- Latanoprost Impurity 18 (CAS CATO-C4X-194118)
- Latanoprost Impurity 24 (CAS CATO-C4X-194124)
- Latanoprost Impurity 16 (CAS CATO-C4X-194116)
- Latanoprost Impurity 26 (CAS CATO-C4X-194126)
- Latanoprost Impurity 19 (CAS CATO-C4X-194119)
Recommended Standards
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