(2-(4-Chloro-3-fluorophenoxy)phenyl)methanol CAS 477887-07-3
| CAS No. | 477887-07-3 |
| Molecular Formula | C13H10ClFO2 |
| Molecular Weight | 252.67 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
(2-(4-Chloro-3-fluorophenoxy)phenyl)methanol (CAS 477887-07-3) is a high-purity analytical reference standard with the molecular formula C13H10ClFO2 and a molecular weight of 252.67 g/mol.
(2-(4-Chloro-3-fluorophenoxy)phenyl)methanol (C13H10ClFO2) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), (2-(4-Chloro-3-fluorophenoxy)phenyl)methanol meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H10ClFO2 |
| Molecular Weight | 252.67 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
Related Chloro Standards
- 5-Chloro-3-ethyl-1-(2-fluorophenyl)-1H-pyrazole-4-carbaldehyde (CAS 1152583-51-1)
- 5-Chloro-3-ethyl-1-(4-fluorophenyl)-1H-pyrazole-4-carbaldehyde (CAS 1152583-77-1)
- 2-Chloro-4-(3-fluoro-4-methoxyphenyl)phenol (CAS 1261892-00-5)
- 5-Chloro-2'-fluoro-3'-methoxy-[1,1'-biphenyl]-3-ol (CAS 1261920-31-3)
- 2-Chloro-4-(4-fluoro-3-methoxyphenyl)phenol (CAS 1261920-40-4)
- 3-Chloro-2'-fluoro-4'-methoxy-[1,1'-biphenyl]-4-ol (CAS 1261931-63-8)
- 4-(3-Chloro-4-methoxyphenyl)-3-fluorophenol (CAS 1261946-56-8)
- 5-Chloro-3-ethyl-1-(3-fluorophenyl)-1H-pyrazole-4-carbaldehyde (CAS 1270722-72-9)
Recommended Standards
- 3-(Benzyloxy)-2-chloro-6-fluorophenol (CAS 1881321-93-2)
- (5-Chloro-1,3-dimethyl-1H-pyrazol-4-yl)(2-fluorophenyl)methanone (CAS 29938-71-4)
- 3-(Benzyloxy)-5-chloro-4-fluorophenol (CAS 1881292-68-7)
- 1-(4-Chloro-2-fluorophenyl)-3,5-dimethyl-1H-pyrazole-4-carbaldehyde (CAS 2379321-22-7)
- (3-Fluorophenyl)(6-methoxypyridin-2-yl)methanone (CAS 1187164-83-5)
- 1,2-Bis(2,4-dichlorophenyl)ethane-1,2-dione (CAS 54696-56-9)
- 3-Oxo-2,3,5,6,7,8-hexahydroisoquinoline-4-carbonitrile (CAS 53661-31-7)
- (2S,4R)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)-4-(4-bromobenzyl)pyrrolidine-2-carboxylic acid (CAS 959580-40-6)
- 2-Methyl-3-(((methylthio)methyl)thio)furan (CAS 61720-53-4)
- Tetramethylphosphonium chloride (CAS 1941-19-1)
- 3-Methoxy-3'-(trifluoromethyl)-[1,1'-biphenyl]-4-ol (CAS 1261990-39-9)
- 2-((Methoxymethyl)thio)-1-methyl-1H-imidazole (CAS 682809-88-7)
- 1-(2-(1,3-Dioxolan-2-yl)ethyl)-1H-imidazole (CAS 798571-74-1)
- Neuropeptide Y (2-36), amide, porcine (CAS 102961-52-4)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com