1-(Morpholin-4-yl)-2-{4-[4-(thiophen-2-yl)pyrimidin-2-yl]phenoxy}ethan-1-one CAS 477888-46-3
| CAS No. | 477888-46-3 |
| Molecular Formula | C20H19N3O3S |
| Molecular Weight | 381.45 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 1-(Morpholin-4-yl)-2-{4-[4-(thiophen-2-yl)pyrimidin-2-yl]phenoxy}ethan-1-one is closely related to a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies 1-(Morpholin-4-yl)-2-{4-[4-(thiophen-2-yl)pyrimidin-2-yl]phenoxy}ethan-1-one (CAS 477888-46-3), a certified reference material (molecular formula C20H19N3O3S, MW 381.45 g/mol) for analytical method development and quality control.
Structurally, 1-(Morpholin-4-yl)-2-{4-[4-(thiophen-2-yl)pyrimidin-2-yl]phenoxy}ethan-1-one (C20H19N3O3S) contains a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 13.0, corresponding to approximately 13 ring(s) or double-bond equivalent(s). With a molecular weight of 381.45 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H19N3O3S |
| Molecular Weight | 381.45 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Morpholin Standards
- 6-{morpholin-4-yl[4-(trifluoromethyl)phenyl]methyl}-1,3-dioxaindan-5-ol (CAS 289657-30-3)
- (6-Morpholin-4-yl-3-nitro-4-trifluoromethyl-pyridin-2-ylsulfanyl)-acetic acid methyl ester (CAS 1089330-44-8)
- 5-(Morpholin-4-yl)-6-phenyl-3-[3-(trifluoromethyl)phenyl]-1,2,4-triazine (CAS 866143-26-2)
- 5-(Morpholin-4-yl)-3-phenyl-7-(phenylamino)-1,4-thiazepine-6-carbonitrile (CAS 165824-80-6)
- 3-[2-(morpholin-4-yl)ethyl]-6-phenyl-2-sulfanyl-3h,4h-thieno[3,2-d]pyrimidin-4-one (CAS 742118-91-8)
- (Z)-{[4-(morpholin-4-yl)-3-nitrophenyl]methylidene}amino 4-fluorobenzoate (CAS 339019-89-5)
- (Z)-{[4-(morpholin-4-yl)-3-nitrophenyl]methylidene}amino 2-chlorobenzoate (CAS 339019-91-9)
- 1-(Morpholin-4-yl)-2-(4-{[4-(trifluoromethyl)phenyl]methyl}piperazin-1-yl)ethan-1-one (CAS 329701-88-4)
Recommended Standards
- (R)-2'-(Diphenylphosphino)-6,6'-dimethyl-[1,1'-biphenyl]-2-amine (CAS 636987-17-2)
- 2-((4-Allyl-5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl)thio)-N-(2-methoxyphenyl)acetamide (CAS 578003-91-5)
- (2E)-4-Oxo-4-[[2-(piperidin-1-ylsulfonyl)ethyl]-(pyridin-4-ylmethyl)amino]but-2-enoic acid (CAS 929863-40-1)
- 2-((4-Allyl-5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl)thio)-N-(3-methoxyphenyl)acetamide (CAS 573946-29-9)
- 2-Chloro-5-methanesulfonylthiophene-3-sulfonyl chloride (CAS 887350-82-5)
- (3aR,8aR)-Tetrahydro-2,2-dimethyl-4,4,8,8-tetraphenyl-N,N-bis[(1R)-1-phenylethyl]-1,3-dioxolo[4,5-e][1,3,2]dioxaphosphepin-6-amine (CAS 1226495-37-9)
- 1-Bromo-2,4-difluoro-3-methoxy-5-methylbenzene (CAS 1881332-59-7)
- Tungsten(0) pentacarbonyl-N-pentylisonitrile (CAS 347145-09-9)
- 4-Cyanophenyl butyrate (CAS 29052-10-6)
- Diethyl azetidine-3,3-dicarboxylate (CAS 1011479-74-5)
- N-(5-bromo-2-fluorophenyl)acrylamide (CAS 1156153-35-3)
- tert-Butyl 3-bromo-2-methoxybenzoate (CAS 1820607-75-7)
- Tert-butyl 2-(2-phenoxy-1-((2,2,2-trifluoroethyl)imino)ethyl)hydrazine-1-carboxylate (CAS 1053657-91-2)
- Liraglutide (13-21) TFA Salt (CAS CATO-C4X-19928)
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