(E)-N'-(4-(3-fluoropropoxy)benzylidene)-4-(trifluoromethyl)benzohydrazide CAS 477889-02-4
| CAS No. | 477889-02-4 |
| Molecular Formula | C18H16F4N2O2 |
| Molecular Weight | 368.33 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including (E)-N'-(4-(3-fluoropropoxy)benzylidene)-4-(trifluoromethyl)benzohydrazide.
(E)-N'-(4-(3-fluoropropoxy)benzylidene)-4-(trifluoromethyl)benzohydrazide (CAS 477889-02-4), molecular formula C18H16F4N2O2 and molecular weight 368.33 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of (E)-N'-(4-(3-fluoropropoxy)benzylidene)-4-(trifluoromethyl)benzohydrazide (C18H16F4N2O2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H16F4N2O2 |
| Molecular Weight | 368.33 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Recommended Standards
- 2-(4-Fluorophenyl)-1-{4-[6-(trifluoromethyl)pyrimidin-4-yl]piperazin-1-yl}ethan-1-one (CAS 1775544-36-9)
- 2-((3-Cyanothiophen-2-yl)amino)-2-oxoethyl 2-(3-(trifluoromethyl)phenyl)acetate (CAS 338777-44-9)
- Furan-2-yl(3-((4-(trifluoromethyl)benzo[d]thiazol-2-yl)oxy)azetidin-1-yl)methanone (CAS 1421472-17-4)
- 4-(Oxazol-2-yl)-N-(4-(trifluoromethyl)phenyl)benzenesulfonamide (CAS 646039-66-9)
- 1-Chloroethyl acetate (CAS 5912-58-3)
- 4-chloro-1H-pyrrolo[2,3-c]pyridine-3-sulfonyl chloride (CAS 2231674-38-5)
- 3-ethyl-5-(2,2,2-trifluoroethyl)-1H-1,2,4-triazole (CAS 1248135-05-8)
- 4-Sulfamoylphenylboronic Acid Pinacol Ester (CAS 214360-51-7)
- 4-(4-Methylpiperazin-1-yl)quinazolin-6-amine (CAS 338797-07-2)
- 2-Chloro-3-nitro-5-(trifluoromethyl)benzoic Acid (CAS 22227-59-4)
- 2-(2,4-Dichlorophenyl)pyrimidin-4-amine (CAS 1250544-45-6)
- (1R,4S)-4-(phenylamino)-1,2,3,4-tetrahydronaphthalen-1-ol (CAS 2053652-28-9)
- Methyl 4-(4-fluorophenyl)-2-methyloxazole-5-carboxylate (CAS 914287-71-1)
- Tau Peptide (379-408) trifluoroacetate salt (CAS 1246357-53-8)
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