3-(1,1-Difluorobut-3-en-1-yl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine CAS 477889-55-7
| CAS No. | 477889-55-7 |
| Molecular Formula | C11H8F5N3 |
| Molecular Weight | 277.19 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
3-(1,1-Difluorobut-3-en-1-yl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine (CAS 477889-55-7) is a high-purity analytical reference standard with the molecular formula C11H8F5N3 and a molecular weight of 277.19 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution, 3-(1,1-Difluorobut-3-en-1-yl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine is typically off-white to pale yellow low-melting solid. Its solid-state physicochemical attributes — including a molecular weight of 277.19 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 3-(1,1-Difluorobut-3-en-1-yl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H8F5N3 |
| Molecular Weight | 277.19 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Difluorobut Standards
- (E)-2,3-Difluorobut-2-Enedioic Acid (CAS 2714-32-1)
- Ethyl 4,4-difluorobut-2-enoate (CAS 1992-97-8)
- Ethyl 4,4-difluorobut-2-ynoate (CAS 129922-56-1)
- (E)-4,4-Difluorobut-2-enoic acid (CAS 37759-73-2)
- 4,4-Difluorobut-2-enoic acid (CAS 944328-71-6)
- 4,4-Difluorobut-2-ynoic acid (CAS 110680-65-4)
- 2,2-Difluorobut-3-en-1-ol (CAS 182439-31-2)
Recommended Standards
- 2-(1H-1,2,4-Triazol-1-yl)benzene-1,3,5-tricarboxylic acid (CAS 2111824-48-5)
- 4-(2,4-Dichlorophenyl)-5-(methylsulfanyl)-1,2,3-thiadiazole (CAS 338409-02-2)
- (S)-(+)-Clenbuterol (CAS 50499-60-0)
- 4-(2,5-Dichlorothiophen-3-yl)-2-(methylsulfanyl)pyrimidine (CAS 339020-26-7)
- 1-((Benzyloxy)carbonyl)-4-hydroxypyrrolidine-2-carboxylic acid (CAS 91958-67-7)
- 2-(1-(4-Methoxyphenyl)cyclopropyl)acetic acid (CAS 1225503-00-3)
- 2'-Methoxy-[1,1'-biphenyl]-3-sulfonyl chloride (CAS 1032506-66-3)
- 6-Acetyl-7-hydroxy-2-(2-methoxyphenyl)-4H-chromen-4-one (CAS 126412-03-1)
- 4-Iodo-2-trifluoromethyl-1-trifluoromethylsulfanylbenzene (CAS 1408279-94-6)
- Diethyl 2-(2-(dichloromethylene)cyclohexyl)malonate (CAS 339343-20-3)
- 1028843-19-7 3-(trifluoromethyl)-1H-pyrazol-5-amine 5-TRIFLUOROMETHYL-2H-PYRAZOL-3-YLAMINE (CAS 1028843-19-7)
- 2-(4-Amino-1H-pyrazol-1-yl)acetic acid hydrochloride (CAS 1417569-73-3)
- N-(2-chlorobenzyl)-2-nitroaniline (CAS 126991-21-7)
- Hexapeptide-11 (CAS 161258-30-6)
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