(E)-1-tosyl-N'-(4-(trifluoromethoxy)benzylidene)piperidine-4-carbohydrazide CAS 478030-18-1
| CAS No. | 478030-18-1 |
| Molecular Formula | C21H22F3N3O4S |
| Molecular Weight | 469.48 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
(E)-1-tosyl-N'-(4-(trifluoromethoxy)benzylidene)piperidine-4-carbohydrazide (CAS 478030-18-1), molecular formula C21H22F3N3O4S and molecular weight 469.48 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of (E)-1-tosyl-N'-(4-(trifluoromethoxy)benzylidene)piperidine-4-carbohydrazide (C21H22F3N3O4S) is characterized by a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures (E)-1-tosyl-N'-(4-(trifluoromethoxy)benzylidene)piperidine-4-carbohydrazide under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C21H22F3N3O4S |
| Molecular Weight | 469.48 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related E Standards
- 2-Phenyl-4-tosyl-6-(3-(trifluoromethyl)phenoxy)pyrimidine (CAS 478080-70-5)
- 4-Tosyl Mycophenolic Acid-d (CAS 1185242-13-0)
- Methyl 4-Tosyl Mycophenoate-6-methyl-d (CAS 1185240-84-9)
- Ethyl 1-tosyl-7-(((trifluoromethyl)sulfonyl)oxy)-1H-pyrrolo[3,2-c]pyridine-6-carboxylate (CAS 1207175-44-7)
- 4-(3-Tosyl-2-(tosylmethyl)propanoyl)benzoic Acid (CAS 124243-00-1)
- 1-Tosyl-N-(3-(trifluoromethyl)phenyl)piperidine-4-carboxamide (CAS 478047-59-5)
- 5-Tosyl-2-deoxy Guanosine (CAS 109954-64-5)
- 1-Tosyl-a,a-diphenyl-3-pyrrolidineacetonitrile (CAS 133034-03-4)
Recommended Standards
- N-Benzyloxycarbonyl-4,6-O-phenylmethylene Deoxynojirimycin Diacetate (CAS 153373-52-5)
- 3-((4-Nitrobenzyl)thio)-1-(3-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile (CAS 692287-36-8)
- N-Methoxy-N-methyl-4-oxo-5-{[3-(trifluoromethyl)phenyl]methyl}-1H,2H,3H,3aH,4H,5H-pyrrolo[1,2-a]quinoxaline-7-sulfonamide (CAS 1022903-91-8)
- 4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-4-(2-carboxyethyl)heptanedioic acid (CAS 798576-99-5)
- Ethyl (2-(pyridin-2-ylamino)phenyl)carbamate (CAS 89659-78-9)
- 2-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethanamine (CAS 138500-90-0)
- tert-Butyl (1S,3S,5S)-3-cyano-2-azabicyclo[3.1.0]hexane-2-carboxylate (CAS 361442-57-1)
- Methyl 2-(cyclopent-1-en-1-yl)acetate (CAS 21622-07-1)
- (E)-N-Hydroxyhex-3-enamide (CAS 114142-24-4)
- 6-Ethyl-4-oxo-4H-chromene-3-carbonitrile (CAS 50743-19-6)
- Cefixime Trihydrate (CAS 125110-14-7)
- (S)-N-((S)-1-(((S)-1-Amino-4-(methylthio)-1-oxobutan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-1-((5-aminopentanoyl)-L-phenylalanyl-L-phenylalanyl)-N-methylpyrrolidine-2-carboxamide (CAS 133156-06-6)
- 4-(2,2-Dimethoxyethyl)bicyclo[2.2.1]Heptane-1-carboxylic acid (CAS 2306271-02-1)
- Semaglutide Impurity 184 (CAS CATO-C4X-2226184)
Why CATO?
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