2-(4-(4-Fluorophenyl)piperazin-1-yl)-1-(thiophen-2-yl)ethan-1-one CAS 478043-79-7

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-(4-(4-Fluorophenyl)piperazin-1-yl)-1-(thiophen-2-yl)ethan-1-one.

2-(4-(4-Fluorophenyl)piperazin-1-yl)-1-(thiophen-2-yl)ethan-1-one (CAS 478043-79-7) is a high-purity analytical reference standard with the molecular formula C16H17FN2OS and a molecular weight of 304.38 g/mol.

The molecular framework of 2-(4-(4-Fluorophenyl)piperazin-1-yl)-1-(thiophen-2-yl)ethan-1-one (C16H17FN2OS) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, sulfur-containing functionality, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

As a certified reference material (CRM), 2-(4-(4-Fluorophenyl)piperazin-1-yl)-1-(thiophen-2-yl)ethan-1-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

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