4-{4-[4-(Trifluoromethyl)benzoyl]piperazino}benzenecarbonitrile CAS 478046-82-1
| CAS No. | 478046-82-1 |
| Molecular Formula | C19H16F3N3O |
| Molecular Weight | 359.35 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), 4-{4-[4-(Trifluoromethyl)benzoyl]piperazino}benzenecarbonitrile meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
4-{4-[4-(Trifluoromethyl)benzoyl]piperazino}benzenecarbonitrile (CAS 478046-82-1), molecular formula C19H16F3N3O and molecular weight 359.35 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 4-{4-[4-(Trifluoromethyl)benzoyl]piperazino}benzenecarbonitrile (C19H16F3N3O) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C19H16F3N3O |
| Molecular Weight | 359.35 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Trifluoromethyl Standards
- 2-(3-Methyl-5-(trifluoromethyl)-1H-pyrazol-1-yl)-N-(thiazol-2-yl)thiazole-4-carboxamide (CAS 955976-61-1)
- 4-(4-(3-(Trifluoromethyl)benzoyl)piperazin-1-yl)benzonitrile (CAS 551931-11-4)
- (2-(3-Methyl-5-(trifluoromethyl)-1H-pyrazol-1-yl)thiazol-4-yl)(4-methylpiperazin-1-yl)methanone (CAS 956705-37-6)
- 2-{4-[3-(trifluoromethyl)benzenesulfonamido]phenyl}acetic acid (CAS 735305-35-8)
- 2-Phenyl-2-((3-(trifluoromethyl)phenyl)sulfonamido)acetic acid (CAS 250714-41-1)
- 4-(((3-(Trifluoromethyl)phenyl)sulfonamido)methyl)benzoic acid (CAS 690645-93-3)
- ethyl 5-(trifluoromethyl)-1-[4-(trifluoromethyl)-1,3-thiazol-2-yl]-1H-pyrazole-4-carboxylate (CAS 956193-97-8)
- 5,5'-Bis-Trifluoromethyl-2,2'-Dichlorobiphenyl (CAS 99686-52-9)
Recommended Standards
- 4-(8-Hydroxy-6-sulfonaphthalen-2-ylamino)benzoicacid (CAS 71486-49-2)
- Ethyl 2-((2-((3-fluorophenoxy)methyl)-3-oxoisoindolin-1-yl)oxy)acetate (CAS 866010-43-7)
- Methyl 4-[4-(4-fluorophenyl)piperazino]-3-nitrobenzenecarboxylate (CAS 478246-25-2)
- 4-(3-(2-Fluorobenzoyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)benzamide (CAS 858118-29-3)
- N-Butyl-1,2,3,4-tetrahydroacridine-9-carboxamide (CAS 7197-79-7)
- (2-Fluoro-4-methyl-5-((4-methylpiperazin-1-yl)sulfonyl)phenyl)boronic acid (CAS 1704121-45-8)
- 4-(2,5-Dioxopyrrolidin-1-yl)-N,N-diethylbenzenesulfonamide (CAS 112167-35-8)
- Methyl Ester 4-chloro-α-propyl-benzeneacetic Acid (CAS 59667-49-1)
- 1,3,4,5-Tetrahydrobenzo[cd]indol-4-amine (CAS 77963-70-3)
- 5-Chloro-1-methyl-3-(piperazin-1-yl)pyrazin-2(1H)-one (CAS 1269531-03-4)
- Amphotericin B Impurity 27 (CAS CATO-C4X-184427)
- (R)-2-Trifluoromethylpyrrolidine-1-sulfonyl chloride (CAS 1389310-08-0)
- 6-Bromo-4-ethynylquinoline (CAS 1319205-85-0)
- Semaglutide impurity 23 (CAS CATO-C4X-222623)
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