2-(Methylthio)-6-(trifluoromethyl)nicotinonitrile CAS 478050-35-0
| CAS No. | 478050-35-0 |
| Molecular Formula | C8H5F3N2S |
| Molecular Weight | 218.20 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2-(Methylthio)-6-(trifluoromethyl)nicotinonitrile (C8H5F3N2S) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, sulfur-containing functionality, fluorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
2-(Methylthio)-6-(trifluoromethyl)nicotinonitrile (CAS 478050-35-0) is a high-purity analytical reference standard with the molecular formula C8H5F3N2S and a molecular weight of 218.20 g/mol.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2-(Methylthio)-6-(trifluoromethyl)nicotinonitrile meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H5F3N2S |
| Molecular Weight | 218.20 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Methylthio Standards
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Recommended Standards
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- 362640-56-0 2-Methyl-4-(trifluoromethyl)benzonitrile MFCD13185724 (CAS 362640-56-0)
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- (R)-1-(4,4-Difluoroisochroman-8-yl)ethan-1-amine (CAS 2488795-17-9)
- 1-(Piperidin-4-yl)-1H-imidazo[4,5-b]pyridine hydrochloride (CAS 1370587-23-7)
- 59880-97-6 Chemotactic peptide F-Met-Leu-Phe L-Phenylalanine, N-(N-(N-formyl-L-methionyl)-L-leucyl)- N-Formyl-L-methionyl-L-leucyl-L-phenylalanine N-Formyl-Met-Leu-Phe N-Formylmethionine leucyl-phenylalanine fMLF fMLP (misnomer but widely used) (CAS 59880-97-6)
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