5-[(3,4-Dichlorophenoxy)methyl]-3-phenyl-1,2-oxazole CAS 478066-22-7
| CAS No. | 478066-22-7 |
| Molecular Formula | C16H11Cl2NO2 |
| Molecular Weight | 320.17 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 5-[(3,4-Dichlorophenoxy)methyl]-3-phenyl-1,2-oxazole.
CATO supplies 5-[(3,4-Dichlorophenoxy)methyl]-3-phenyl-1,2-oxazole (CAS 478066-22-7), a certified reference material (molecular formula C16H11Cl2NO2, MW 320.17 g/mol) for analytical method development and quality control.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, 5-[(3,4-Dichlorophenoxy)methyl]-3-phenyl-1,2-oxazole is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 320.17 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H11Cl2NO2 |
| Molecular Weight | 320.17 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Dichlorophenoxy Standards
- 4-((2,6-Dichlorophenoxy)methyl)-1-phenyl-1H-1,2,3-triazole (CAS 135034-74-1)
- 5-((2,4-Dichlorophenoxy)methyl)-3-phenylisoxazole (CAS 672951-45-0)
- 2-(2-((2,5-Dichlorophenoxy)methyl)morpholino)acetamide (CAS 1706454-10-5)
- 3-((2,4-Dichlorophenoxy)methyl)-5-phenyl-1,2,4-oxadiazole (CAS 4780-17-0)
- 3-(3,4-Dichlorophenoxy)-1-methylquinoxalin-2(1H)-one (CAS 338774-58-6)
- 3-(3,5-Dichlorophenoxy)-1-methyl-1,2-dihydroquinoxalin-2-one (CAS 338774-61-1)
- 5-Acetyl-2-(2,4-dichlorophenoxy)-6-methylnicotinonitrile (CAS 303146-63-6)
- 5-(1-(2,4-Dichlorophenoxy)ethyl)-4-ethyl-4H-1,2,4-triazole-3-thiol (CAS 588673-89-6)
Recommended Standards
- 5,7-Dichloro-2-(methyl(pyridin-2-yl)amino)quinolin-8-ol (CAS 648896-68-8)
- 6-Chloro-2-(4-chlorophenyl)imidazo[1,2-α]pyridine-3-acetamide (CAS 82626-73-1)
- 5-(3,4-Dichlorophenyl)-3-(phenoxymethyl)-1,2-oxazole (CAS 339019-86-2)
- 6-Chloro-N-(3-chlorophenyl)-2H-chromene-3-carboxamide (CAS 338759-58-3)
- 4-(1h-1,2,4-Triazol-1-yl)butanoic acid (CAS 158147-52-5)
- Azetidin-1-yl-(3,4-difluorophenyl)-methanone (CAS 863505-11-7)
- N-(9-((2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-8-methoxy-9H-purin-6-yl)benzamide (CAS 139639-83-1)
- N-(2,3,4-trimethoxybenzyl)pentan-3-amine hydrobromide (CAS 1609400-59-0)
- 5-Bromevalerate ethyl ester (CAS 14660-52-7)
- (S)-2-hydroxy-2-(4-iodophenyl)ethyl acetate (CAS 2135714-04-2)
- 5-(Pyrimidin-5-yl)thiophene-2-carboxylic acid (CAS 893738-11-9)
- Methyl 4-(methylamino)tetrahydro-2H-pyran-2-carboxylate (CAS 1543413-56-4)
- 6-Benzyloxypurine (CAS 57500-07-9)
- Semaglutide Impurity 5 (CAS 23406-82-8)
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