2-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N1,N3-bis(3-methoxybenzyl)malonamide CAS 478077-72-4
| CAS No. | 478077-72-4 |
| Molecular Formula | C25H23ClF3N3O4 |
| Molecular Weight | 521.92 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 2-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N1,N3-bis(3-methoxybenzyl)malonamide is closely related to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies 2-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N1,N3-bis(3-methoxybenzyl)malonamide (CAS 478077-72-4), a certified reference material (molecular formula C25H23ClF3N3O4, MW 521.92 g/mol) for analytical method development and quality control.
The molecular framework of 2-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N1,N3-bis(3-methoxybenzyl)malonamide (C25H23ClF3N3O4) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C25H23ClF3N3O4 |
| Molecular Weight | 521.92 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
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