5-(Benzenesulfonyl)-4-(2,4-difluorophenoxy)-2-phenylpyrimidine CAS 478080-97-6
| CAS No. | 478080-97-6 |
| Molecular Formula | C22H14F2N2O3S |
| Molecular Weight | 424.42 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 5-(Benzenesulfonyl)-4-(2,4-difluorophenoxy)-2-phenylpyrimidine.
5-(Benzenesulfonyl)-4-(2,4-difluorophenoxy)-2-phenylpyrimidine (CAS 478080-97-6), molecular formula C22H14F2N2O3S and molecular weight 424.42 g/mol, is a CATO reference standard with documented purity and traceability.
5-(Benzenesulfonyl)-4-(2,4-difluorophenoxy)-2-phenylpyrimidine (C22H14F2N2O3S) contains a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 5-(Benzenesulfonyl)-4-(2,4-difluorophenoxy)-2-phenylpyrimidine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H14F2N2O3S |
| Molecular Weight | 424.42 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Benzenesulfonyl Standards
- 4-(Benzenesulfonyl)-5-(4-chlorophenyl)-1-(4-methoxyphenyl)-1H-pyrazole (CAS 318951-66-5)
- 4-[(Benzenesulfonyl)methyl]-6-[(2,4-dichlorophenyl)sulfanyl]-2-methylpyrimidine (CAS 338960-51-3)
- 3-(Benzenesulfonyl)-4,6-dimethyl-2-{[3-(trifluoromethyl)phenyl]sulfanyl}pyridine (CAS 339017-02-6)
- 1-(Benzenesulfonyl)-N-(4-bromophenyl)piperidine-4-carboxamide (CAS 591238-02-7)
- 3-(Benzenesulfonyl)-2-(4-chlorobenzoyl)-5-(trifluoromethyl)pyridine (CAS 338960-06-8)
- N'-[1-(Benzenesulfonyl)piperidin-4-ylidene]-3,4-dichlorobenzohydrazide (CAS 478248-25-8)
- 5-(Benzenesulfonyl)-4-[(4-fluorophenyl)sulfanyl]-2-phenylpyrimidine (CAS 478081-01-5)
- (2E)-3-[1-(Benzenesulfonyl)-1H-indol-5-yl]-N-(oxan-2-yloxy)prop-2-enamide (CAS 951655-99-5)
Recommended Standards
- 4-Benzoyl-3-methyl-1-{[4-(trifluoromethyl)phenyl]methyl}-1,2,3,4-tetrahydroquinoxalin-2-one (CAS 317822-15-4)
- N-(4-methoxyphenyl)-1-(1-methyl-2-(3-(trifluoromethyl)phenoxy)-1H-indol-3-yl)methanimine (CAS 866017-46-1)
- 1775384-87-6 2,4-Dimethoxy-N-{1-[2-methyl-6-(trifluoromethyl)pyrimidin-4-yl]piperidin-4-yl}benzamide MFCD28805951 (CAS 1775384-87-6)
- 37793-53-6 4-(N-((2-Amino-4-oxo-3,4-dihydropteridin-6-yl)methyl)-2,2,2-trifluoroacetamido)benzoic acid AC1NCZ59 N10-Trifluroacetylpteroic acid (CAS 37793-53-6)
- 1-(2-Methylphenyl)cyclohexan-1-amine (CAS 118560-04-6)
- n-(5-Amino-4-(benzo[d]thiazol-2-yl)-3-oxo-2,3-dihydro-1h-pyrrol-1-yl)thiophene-2-carboxamide (CAS 847783-78-2)
- 2-Amino-2-methyl-3-(1h-pyrazol-1-yl)propanamide (CAS 1249366-88-8)
- 1-[3-(Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-3-(trichloroacetyl)urea (CAS 2377612-05-8)
- 1-(Diethoxymethyl)-4-methylbenzene (CAS 2403-59-0)
- H-Glu-Asp-OH (CAS 3918-84-1)
- 2-Methyl-2,8-diazaspiro[4.5]decane (CAS 1061873-16-2)
- N-(3-chloropyridin-2-yl)thiophene-2-carboxamide (CAS 355831-67-3)
- 3-Amino-2-((1-methyl-1h-pyrazol-4-yl)methyl)propanamide (CAS 1152506-05-2)
- Anti-Inflammatory Peptide 3 (CAS 118850-73-0)
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