(5-Chloro-2-nitrophenyl)(4-(2-fluorophenyl)piperazin-1-yl)methanone CAS 478249-15-9
| CAS No. | 478249-15-9 |
| Molecular Formula | C17H15ClFN3O3 |
| Molecular Weight | 363.77 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
(5-Chloro-2-nitrophenyl)(4-(2-fluorophenyl)piperazin-1-yl)methanone (CAS 478249-15-9), molecular formula C17H15ClFN3O3 and molecular weight 363.77 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, (5-Chloro-2-nitrophenyl)(4-(2-fluorophenyl)piperazin-1-yl)methanone is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 363.77 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C17H15ClFN3O3 |
| Molecular Weight | 363.77 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related Chloro Standards
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Recommended Standards
- N-(4-chlorophenyl)-2-(2,3,5,6-tetrafluoro-4-methylphenyl)hydrazine-1-carbothioamide (CAS 946387-19-5)
- 4-(4-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)phenoxy)benzene-1-sulfonyl chloride (CAS 677326-81-7)
- dimethyl 5-[(chloroacetyl)amino]-3-(2-methoxy-2-oxoethyl)thiophene-2,4-dicarboxylate (CAS 854357-38-3)
- Ethyl 2-(2-amino[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)-3-(2-chloro-6-fluorophenyl)propanoate (CAS 477856-20-5)
- 5-Methyl-1-(propan-2-yl)-1h-pyrazole-4-carbaldehyde (CAS 1006495-89-1)
- 7-Oxa-2-azaspiro[4.5]Decan-3-one (CAS 1487759-95-4)
- N-{4-[(2-Acetylanilino)sulfonyl]phenyl}acetamide (CAS 294885-61-3)
- 5-Cyclopropoxy-4-fluoropicolinaldehyde (CAS 1243472-29-8)
- 1,2,5-Tribromo-3-(trifluoromethyl)benzene (CAS 89642-34-2)
- 2,2,4-Trimethyl-1,2,3,4-tetrahydroquinoline-8-carboxylic acid (CAS 1256628-15-5)
- 4-Phenoxy-1H-indole-3-acetonitrile (CAS 1146298-21-6)
- N-(9-((2R,3R,4R,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3,4-bis((tert-butyldimethylsilyl)oxy)tetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide (CAS 160513-05-3)
- ({[Cyclohexyl(4-methylbenzyl)amino]-carbonothioyl}amino)acetic acid (CAS 656816-07-8)
- Tirzepatide Impurity 36 (CAS CATO-C4X-324036)
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