4-((5-Bromo-2-hydroxybenzylidene)amino)-3-(2-methoxyphenyl)-1H-1,2,4-triazole-5(4H)-thione CAS 478256-64-3
| CAS No. | 478256-64-3 |
| Molecular Formula | C16H13BrN4O2S |
| Molecular Weight | 405.27 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-((5-Bromo-2-hydroxybenzylidene)amino)-3-(2-methoxyphenyl)-1H-1,2,4-triazole-5(4H)-thione.
4-((5-Bromo-2-hydroxybenzylidene)amino)-3-(2-methoxyphenyl)-1H-1,2,4-triazole-5(4H)-thione (CAS 478256-64-3) is a high-purity analytical reference standard with the molecular formula C16H13BrN4O2S and a molecular weight of 405.27 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, bromine substitution, 4-((5-Bromo-2-hydroxybenzylidene)amino)-3-(2-methoxyphenyl)-1H-1,2,4-triazole-5(4H)-thione is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 405.27 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 4-((5-Bromo-2-hydroxybenzylidene)amino)-3-(2-methoxyphenyl)-1H-1,2,4-triazole-5(4H)-thione meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H13BrN4O2S |
| Molecular Weight | 405.27 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 4 |
| Sulfur Atoms | 1 |
Related Bromo Standards
- 3-Bromo-2-(4-methoxyphenyl)-4,5-diphenylfuran (CAS 6628-71-3)
- 2-(4-(8-Bromo-2-methyl-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile (CAS 1624261-99-9)
- 6-Bromo-4-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline (CAS 476474-52-9)
- 7-Bromo-4-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline (CAS 476474-61-0)
- N-(3-Bromo-4-methylphenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine (CAS 300842-64-2)
- 7-Bromo-4-(2,4-dimethoxybenzyl)-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione (CAS 428507-46-4)
- 4-Bromo-N-(4-(2,5-dimethyl-1H-pyrrol-1-yl)phenyl)benzenesulfonamide (CAS 866156-51-6)
- 2-bromo-1-(5-(tert-butyl)-[1,1'-biphenyl]-2-yl)-1H-benzo[d]imidazole (CAS CATO-CIM-105076)
Recommended Standards
- 2-{[4-(4-bromophenyl)-5-(pyridin-4-yl)-4h-1,2,4-triazol-3-yl]sulfanyl}acetohydrazide (CAS 893727-33-8)
- 5-(Methoxycarbonyl)-1-tosyl-1H-pyrrole-3-boronic Acid Pinacol Ester (CAS 869886-86-2)
- 2-[4-(3,4-Dichloro-benzyl)-morpholin-2-ylmethyl]-isoindole-1,3-dione (CAS 407640-38-4)
- N-(2-Bromophenyl)-2-((3-(2-hydroxyphenyl)-1H-1,2,4-triazol-5-yl)thio)acetamide (CAS 336180-29-1)
- Previtamin D2 (~90%) (CAS 21307-05-1)
- trans-2-Hepten-1-ol (CAS 33467-76-4)
- MSDC-0160, >98% (CAS 146062-49-9)
- (R)-1-(4-bromo-3-chlorophenyl)ethan-1-amine (CAS 1213455-11-8)
- N-((11bS)-2,6-dimesityl-4-sulfidodinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-yl)-1,1,1-trifluoromethanesulfonamide (CAS 1042671-80-6)
- 4-(1,1,2-Trifluoro-2-(trifluoromethoxy)ethoxy)benzoic acid (CAS 1845695-98-8)
- (2R,3aR,6aR)-Octahydrocyclopenta[b]pyrrole-2-carboxylic acid (CAS 128900-19-6)
- 3-Allyl-5-methyl-3-(pyridin-2-yl)dihydrofuran-2(3H)-one (CAS 71824-63-0)
- Vemurafenib-d5 (CAS 1365986-90-8)
- Semaglutide impurity 206 (CAS CATO-C4X-2226206)
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