(E)-({6-chloro-2-phenylimidazo[1,2-a]pyridin-3-yl}methylidene)amino 4-methylbenzoate CAS 478257-27-1
| CAS No. | 478257-27-1 |
| Molecular Formula | C22H16ClN3O2 |
| Molecular Weight | 389.83 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including (E)-({6-chloro-2-phenylimidazo[1,2-a]pyridin-3-yl}methylidene)amino 4-methylbenzoate.
(E)-({6-chloro-2-phenylimidazo[1,2-a]pyridin-3-yl}methylidene)amino 4-methylbenzoate (CAS 478257-27-1) is a high-purity analytical reference standard with the molecular formula C22H16ClN3O2 and a molecular weight of 389.83 g/mol.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, (E)-({6-chloro-2-phenylimidazo[1,2-a]pyridin-3-yl}methylidene)amino 4-methylbenzoate is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 389.83 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), (E)-({6-chloro-2-phenylimidazo[1,2-a]pyridin-3-yl}methylidene)amino 4-methylbenzoate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H16ClN3O2 |
| Molecular Weight | 389.83 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related E Standards
- 4-Chloro-6-(5-((2-morpholinoethyl)amino)benzo[d]isoxazol-3-yl)benzene-1,3-diol (CAS 1012788-65-6)
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- 7-Butyl-4-chloro-3,8,9-trimethoxybenzo[g]quinoline-5,10-dione (CAS 61186-53-6)
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- 4-((2-Chloro-5-nitrobenzylidene)amino)-3-(2-methoxyphenyl)-1H-1,2,4-triazole-5(4H)-thione (CAS 478257-54-4)
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- 2-(6-(4-(2-Chloro-5-fluorophenoxy)piperidin-1-yl)pyridazin-3-yl)-5-methyl-1,3,4-oxadiazole (CAS 944808-88-2)
Recommended Standards
- 2-Amino-5-(4-chlorophenyl)-5-[(3,4,5-trimethoxyphenyl)methyl]-4,5-dihydro-1H-imidazol-4-one (CAS 1354926-37-6)
- 1-[(4-Chlorophenyl)sulfanyl]-4-[(4-fluorophenoxy)methyl]-2-nitrobenzene (CAS 477869-49-1)
- 2-Amino-5-(3-chlorophenyl)-5-[(3,4,5-trimethoxyphenyl)methyl]-4,5-dihydro-1H-imidazol-4-one (CAS 1354925-02-2)
- 2-(4-Chlorobenzamido)-N-(4-fluorobenzyl)thiazole-4-carboxamide (CAS 954682-18-9)
- 5-(3-ethylbenzyl)-1,3-thiazol-2-amine (CAS 923153-23-5)
- N-(3-aminopropyl)-2,4-dichlorobenzamide hydrochloride (CAS 1836461-52-9)
- (2R,3S,5R)-5-(6-amino-9H-purin-9-yl)-2-(hydroxymethyl)tetrahydrofuran-3-yl dihydrogen phosphate (CAS 15731-72-3)
- 3-BROMO-5-CHLORO-2-NITROPHENOL (CAS 1936363-37-9)
- 4-(1H-Benzo[d]imidazol-2-yl)benzamide (CAS 145855-32-9)
- 4-Bromo-6-(trifluoromethoxy)benzo[d]thiazole-2(3H)-thione (CAS 1215206-47-5)
- 1-[(1-Boc-4-piperidyl)methyl]-1H-pyrazole-4-boronic Acid Pinacol Ester (CAS 1092563-72-8)
- Methyl 4-cyano-5-hydroxy-2-methoxybenzoate (CAS 1806268-97-2)
- 2-((1-(4-Acetylphenyl)-1H-pyrrol-2-yl)methylene)malononitrile (CAS 383147-61-3)
- Valosin Peptide (VQY), porcine (CAS 99510-37-9)
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