2-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N1,N3-bis((5-methylfuran-2-yl)methyl)malonamide CAS 478257-88-4
| CAS No. | 478257-88-4 |
| Molecular Formula | C21H19ClF3N3O4 |
| Molecular Weight | 469.84 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 469.84 g/mol gives 2-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N1,N3-bis((5-methylfuran-2-yl)methyl)malonamide distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
2-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N1,N3-bis((5-methylfuran-2-yl)methyl)malonamide (CAS 478257-88-4), molecular formula C21H19ClF3N3O4 and molecular weight 469.84 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 2-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N1,N3-bis((5-methylfuran-2-yl)methyl)malonamide (C21H19ClF3N3O4) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H19ClF3N3O4 |
| Molecular Weight | 469.84 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
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Recommended Standards
- VORUCICLIB (CAS 1000023-04-0)
- Regadenoson Impurity 53 (CAS CATO-C4X-198553)
- Lumiracoxib acyl-β-D-glucuronide (CAS 697287-17-5)
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- 3-(1-(Thiophene-3-carbonyl)piperidin-4-yl)thiazolidine-2,4-dione (CAS 1787881-65-5)
- 2-(2-(Benzyloxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 1027757-13-6)
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- 3-(2,3-dihydro-1,4-benzodioxin-5-yl)-1,2-oxazol-5-amine (CAS 1156753-33-1)
- 2-(Dimethylcarbamoyl)phenylboronic Acid (CAS 874219-16-6)
- 7-Bromo-4,4-dimethyl-1,2,3,4-tetrahydroquinoline (CAS 158326-77-3)
- Resmetirom Impurity 45 (CAS CATO-C4X-291245)
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