5-Bromo-2-(1H-pyrrol-1-yl)pyrimidine CAS 478258-70-7
| CAS No. | 478258-70-7 |
| Molecular Formula | C8H6BrN3 |
| Molecular Weight | 224.06 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
5-Bromo-2-(1H-pyrrol-1-yl)pyrimidine (CAS 478258-70-7) is a high-purity analytical reference standard with the molecular formula C8H6BrN3 and a molecular weight of 224.06 g/mol.
The molecular framework of 5-Bromo-2-(1H-pyrrol-1-yl)pyrimidine (C8H6BrN3) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H6BrN3 |
| Molecular Weight | 224.06 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 3 |
Related Bromo Standards
- 2-Bromo-5-(1H-pyrrol-1-yl)pyrazine (CAS 1027512-24-8)
- 7-Bromo-1,8-naphthyridin-2-amine (CAS 104917-29-5)
- 4-Bromo-2-(1H-imidazol-1-yl)pyridine (CAS 1142194-29-3)
- 4-Bromo-2-(1H-pyrazol-1-yl)pyridine (CAS 1159814-68-2)
- 7-Bromo-8-methylpyrido[2,3-b]pyrazine (CAS 116605-69-7)
- 4-Bromo-1-phenyl-1H-1,2,3-triazole (CAS 116933-01-8)
- 4-(4-Bromo-1-pyrazolyl)pyridine (CAS 1179072-77-5)
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Recommended Standards
- 5-Bromo-2-(1H-pyrazol-3-yl)pyridine (CAS 811464-25-2)
- 6-Bromoquinazolin-4-amine (CAS 21419-48-7)
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- 7-Bromo-6-methylpyrido[2,3-b]pyrazine (CAS 857203-29-3)
- 1-(1-(1-(Methylsulfonyl)-1H-pyrazol-3-yl)ethyl)-1H-1,2,4-triazole (CAS 400077-64-7)
- 7-bromo-2-ethyl-6-methyl-indazole (CAS 2725791-25-1)
- 2-Phenyl-2H-benzo[e][1,3]oxazin-4(3H)-one (CAS 6629-80-7)
- 1-(5-Ethylpyrimidin-2-yl)piperidin-4-ol (CAS 1001397-29-0)
- N-(4-Ethylphenyl)-2-(4-methylpiperazin-1-yl)acetamide hydrochloride (CAS 1047974-81-1)
- 3-(3-Bromophenyl)-1-(2,4-dichlorophenyl)propan-1-one (CAS 898760-69-5)
- 6-Ethoxyquinoline-4-carboxylic acid (CAS 525-39-3)
- 2-Acetamidononanoic acid (CAS 73404-08-7)
- 2-(Thiazol-2-yl)-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3(2H)-dione (CAS 16132-04-0)
- semaglutide (CAS 782487-28-9)
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