Ethyl 6-amino-2-(((4-chlorophenyl)thio)methyl)-5-cyano-4-(4-fluorophenyl)-4H-pyran-3-carboxylate CAS 478260-23-0
| CAS No. | 478260-23-0 |
| Molecular Formula | C22H18ClFN2O3S |
| Molecular Weight | 444.91 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Ethyl 6-amino-2-(((4-chlorophenyl)thio)methyl)-5-cyano-4-(4-fluorophenyl)-4H-pyran-3-carboxylate is closely related to a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Ethyl 6-amino-2-(((4-chlorophenyl)thio)methyl)-5-cyano-4-(4-fluorophenyl)-4H-pyran-3-carboxylate (CAS 478260-23-0) is a high-purity analytical reference standard with the molecular formula C22H18ClFN2O3S and a molecular weight of 444.91 g/mol.
Ethyl 6-amino-2-(((4-chlorophenyl)thio)methyl)-5-cyano-4-(4-fluorophenyl)-4H-pyran-3-carboxylate (C22H18ClFN2O3S) contains a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures Ethyl 6-amino-2-(((4-chlorophenyl)thio)methyl)-5-cyano-4-(4-fluorophenyl)-4H-pyran-3-carboxylate under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C22H18ClFN2O3S |
| Molecular Weight | 444.91 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Ethyl Standards
- Methyl 2-amino-4-(3-chloro-4-nitrophenyl)-5-oxo-4H,5H-thiochromeno[4,3-b]pyran-3-carboxylate (CAS 939889-13-1)
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- 2-Amino-7-bromo-4-[2-(trifluoromethyl)phenyl]-4H-benzo[g]chromene-3-carbonitrile (CAS 861208-31-3)
- (R)-2-Amino-3-(hexylthio)propanoic acid (CAS 23884-44-8)
- 3-Amino-5-((2-carboxy-5-(isopentyloxy)phenyl)amino)-4-(isopentyloxy)benzoic acid (CAS 1096879-46-7)
- 2-Amino-4-(4-methoxyphenyl)-7,7-dimethyl-1-(3-nitrophenyl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile (CAS 311318-23-7)
- 3-Amino-N-(2-methoxy-5-(trifluoromethyl)phenyl)-6-(pyridin-4-yl)thieno[2,3-b]pyridine-2-carboxamide (CAS 625370-66-3)
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Recommended Standards
- 4'-(2-Chlorophenyl)-1'-methyl-1'',2,2'',4-tetrahydrodispiro[1-benzopyran-3,3'-pyrrolidine-2',3''-indole]-2'',4-dione (CAS 1164457-72-0)
- Gefitinib Impurity 38 (CAS 847949-50-2)
- Halometasone Impurity 6 (CAS CATO-C4X-14466)
- Melphalan Impurity 25 (CAS CATO-C4X-198825)
- (S)-2-(3-(Benzyl(ethyl)amino)piperidin-1-yl)ethanol (CAS 1353993-70-0)
- Isoguanosine Triacetate (CAS 173098-06-1)
- 2-(4-bromo-2-fluorophenyl)-2-methyloxirane (CAS 1545775-87-8)
- α-(4-Bromophenyl)-α-[2-(dimethyl-d6-amino)ethyl]-3-pyridinemethanol (CAS 1189936-97-7)
- Ilaprazole Impurity 143 (CAS 2230077-52-6)
- 4-Methyl-N-(3-nitrophenyl)benzenesulfonamide (CAS 1576-38-1)
- 55794-28-0 1-(4-Iodophenyl)-2-phenylethan-1-one DTXSID60642283 (CAS 55794-28-0)
- 1,3-Bis(3-hydroxypropyl)urea (CAS 71466-11-0)
- 1-Chloro-2-ethynyl-3-(trifluoromethyl)benzene (CAS 1807792-37-5)
- Peptide Impurity 27 (CAS 1350456-68-6)
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