3-(Difluoromethoxy)benzoic acid CAS 4837-19-8
| CAS No. | 4837-19-8 |
| Molecular Formula | C8H6F2O3 |
| Molecular Weight | 188.13 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies 3-(Difluoromethoxy)benzoic acid (CAS 4837-19-8), a certified reference material (molecular formula C8H6F2O3, MW 188.13 g/mol) for analytical method development and quality control.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system, 3-(Difluoromethoxy)benzoic acid is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 188.13 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 3-(Difluoromethoxy)benzoic acid under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C8H6F2O3 |
| Molecular Weight | 188.13 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | F-containing |
Related Difluoromethoxy Standards
- 5-(difluoromethoxy)pyridine-2-carboxamide (CAS 1803584-72-6)
- 2-(Difluoromethoxy)benzoic acid (CAS 97914-59-5)
- 2-(Difluoromethoxy)isonicotinamide (CAS 2167739-11-7)
- 4-(Difluoromethoxy)benzoic Acid (CAS 4837-20-1)
- 3-(difluoromethoxy)-2-hydroxybenzaldehyde (CAS 1806293-28-6)
- 2-(2-(Difluoromethoxy)phenyl)ethan-1-ol (CAS 1000533-82-3)
- (3-(Difluoromethoxy)benzyl)hydrazine (CAS 1039877-35-4)
- 6-(Difluoromethoxy)-2,5-dimethylpyridin-3-amine (CAS 1188407-32-0)
Recommended Standards
- 2,6-Difluoro-3-methoxybenzoic acid (CAS 886498-30-2)
- 3,4-Difluoro-2-methoxybenzoic acid (CAS 875664-52-1)
- 2,3-Difluoro-6-methoxybenzoic Acid (CAS 773873-26-0)
- 3,4-Difluoro-5-methoxybenzoic acid (CAS 887584-98-7)
- Ethyl 5,6-dihydro-4H-cyclopenta[d]isoxazole-3-carboxylate (CAS 893638-43-2)
- 5-bromonaphthalene-1-sulfonic acid (CAS 162109-23-1)
- (Z)-2-amino-5-(3,4-dimethoxybenzylidene)thiazol-4(5H)-one 1198098-03-1 F1950-0211 (CAS 1198098-03-1)
- 2-Butyl-1-methyl-1,4,5,6,7,8-hexahydrocyclohepta[b]pyrrole (CAS 89506-60-5)
- 1-Chloro-4-(1,3-dibromopropyl)benzene (CAS 19714-76-2)
- 2-(4-Ethoxyphenyl)-1-{2-[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]pyrrolidin-1-yl}ethan-1-one (CAS 1798633-90-5)
- 4-Amino-6-mercaptopyrimidin-2-ol (CAS 1073-82-1)
- (S)-2-((tert-butoxycarbonyl)amino)-3-(3-carbamoylphenyl)propanoic acid (CAS 943449-15-8)
- 4,5-Dimethoxy-2,3-dihydrobenzofuran-3-amine (CAS 748752-43-4)
- Tirzepatide Impurity 52 (CAS CATO-C4X-324052)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com