4-(Difluoromethylsulfonyl)benzoic acid CAS 4837-22-3
| CAS No. | 4837-22-3 |
| Molecular Formula | C8H6F2O4S |
| Molecular Weight | 236.19 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
4-(Difluoromethylsulfonyl)benzoic acid (CAS 4837-22-3), molecular formula C8H6F2O4S and molecular weight 236.19 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system, 4-(Difluoromethylsulfonyl)benzoic acid is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 236.19 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H6F2O4S |
| Molecular Weight | 236.19 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | F-containing |
| Sulfur Atoms | 1 |
Related Difluoromethylsulfonyl Standards
Recommended Standards
- 4-(3-(Trifluoromethyl)phenyl)-1H-pyrrole-3-carbonitrile (CAS 87388-15-6)
- 4-Hydroxy-1-(3,3,3-trifluoropropanoyl)piperidine-4-carbonitrile (CAS 2022446-49-5)
- 3-Difluoromethanesulfonylbenzoic acid (CAS 4837-21-2)
- 5,5,5-Trifluoro-4-hydroxy-4-(1-methyl-1h-imidazol-2-yl)pentan-2-one (CAS 930414-73-6)
- Benproperine Impurity 9 (CAS 124700-66-9)
- N5,N5-dimethylbenzo[c][1,2,5]oxadiazole-4,5-diamine (CAS 504417-77-0)
- Thiazole-4-carbothioic O-acid (CAS 79582-99-3)
- (E)-3-(2-Hydroxy-4-methoxyphenyl)-1-phenylprop-2-en-1-one (CAS 34000-29-8)
- (S)-4-(Amino(carboxy)methyl)benzoic acid hydrochloride (CAS 2109874-13-5)
- Hexazinone Impurity 20 (CAS 51236-16-9)
- 1-tert-Butyl 3-methyl (3R,4R)-rel-4-methylpiperidine-1,3-dicarboxylate (CAS 1009376-53-7)
- 1-Benzyl-4-ethylpiperidin-4-amine (CAS 440101-13-3)
- 5-Methoxy-2-methyl-1-propyl-1h-indole-3-carboxylic acid (CAS 17826-24-3)
- His-Cyclic-Semaglutide (CAS CATO-C4X-2226182)
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