2-Iodo-1-methyl-1H-indole-3-carbonitrile CAS 490039-77-5
| CAS No. | 490039-77-5 |
| Molecular Formula | C10H7IN2 |
| Molecular Weight | 282.08 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2-Iodo-1-methyl-1H-indole-3-carbonitrile (CAS 490039-77-5), molecular formula C10H7IN2 and molecular weight 282.08 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 2-Iodo-1-methyl-1H-indole-3-carbonitrile (C10H7IN2) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, iodine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2-Iodo-1-methyl-1H-indole-3-carbonitrile meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H7IN2 |
| Molecular Weight | 282.08 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | I-containing |
| Nitrogen Atoms | 2 |
Related Iodo Standards
- 6-Iodo-2,2'-bipyridine (CAS 1189970-71-5)
- 7-Iodo-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one (CAS 1203499-29-9)
- 4-Iodo-2-phenylpyrimidine (CAS 1261472-24-5)
- 3-Iodo-2-naphthaldehyde (CAS 1261490-30-5)
- 4-Iodo-2,2'-bipyridine (CAS 160539-03-7)
- 5-Iodo-2,2'-bipyridine (CAS 160539-05-9)
- 4-Iodo-5-phenylpyrimidine (CAS 16879-43-9)
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Recommended Standards
- 2-Bromo-6-(trifluoromethyl)benzo[d]thiazole (CAS 898748-23-7)
- 3-Bromo-5-(trifluoromethyl)phenylisothiocyanate (CAS 955947-86-1)
- 2-Bromo-5-(trifluoromethyl)phenylisothiocyanate (CAS 862902-36-1)
- 3-Iodo-6-phenylpyridazine (CAS 475633-70-6)
- cis-3-fluorocyclobutanol (CAS 1314961-80-2)
- Morpholino(pyrrolidin-3-yl)methanone (CAS 666853-74-3)
- 6-Chloro-4-methoxy-2,3-dihydro-1H-inden-1-one (CAS 1199782-89-2)
- 1-(5-bromo-3-methoxypyridin-2-yl)ethan-1-one (CAS 1211521-17-3)
- (R)-3-(1H-Indol-3-yl)-2-(5-(p-tolylethynyl)thiophene-2-sulfonamido)propanoic acid (CAS 203640-27-1)
- Ethyl 4-oxo-4-(3-(piperidin-1-ylmethyl)phenyl)butanoate (CAS 898793-74-3)
- 3-Azaspiro[5.5]Undecane hemioxalate (CAS 2306276-54-8)
- 4-(4-Fluorophenyl)-3-methylisoxazol-5-amine (CAS 915919-94-7)
- 1-(4-(2-Isopropyl-5-methylphenoxy)phenyl)-5-oxopyrrolidine-3-carboxylic acid (CAS 899762-66-4)
- Tirzepatide Impurity 18 (CAS CATO-C4X-324018)
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