2-(7-Chloro-4-oxo-3,4-dihydroquinazolin-2-yl)acetonitrile CAS 491876-95-0
| CAS No. | 491876-95-0 |
| Molecular Formula | C10H6ClN3O |
| Molecular Weight | 219.63 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2-(7-Chloro-4-oxo-3,4-dihydroquinazolin-2-yl)acetonitrile (C10H6ClN3O) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
CATO supplies 2-(7-Chloro-4-oxo-3,4-dihydroquinazolin-2-yl)acetonitrile (CAS 491876-95-0), a certified reference material (molecular formula C10H6ClN3O, MW 219.63 g/mol) for analytical method development and quality control.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2-(7-Chloro-4-oxo-3,4-dihydroquinazolin-2-yl)acetonitrile meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H6ClN3O |
| Molecular Weight | 219.63 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Chloro Standards
- 8-Chloro-1H-pyrazolo[4,3-c]quinolin-3(2H)-one (CAS 1015605-31-8)
- 6-Chloro-1,2-dihydro-pyrazolo[4,3-c]quinolin-3-one (CAS 1015605-47-6)
- 4-Chloro-6-methoxycinnoline-3-carbonitrile (CAS 1239784-36-1)
- 6-Chloro-1H-pyrazolo[3,4-b][1,8]naphthyridin-3-amine (CAS 1335220-58-0)
- 1-Acetyl-5-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile (CAS 1352395-53-9)
- 8-chloro-3-methyl-3H-[1,2,3]triazolo[4,5-g]quinazoline (CAS 1384081-59-7)
- 6-CHLORO-3H-PYRIMIDO[4,5-B]INDOL-4(9H)-ONE (CAS 1403589-25-2)
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Recommended Standards
- 2-((4-(2-Chloroacetyl)-1H-pyrrol-2-yl)methylene)malononitrile (CAS 866038-31-5)
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- 1-{2-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl}-1H-pyrazole (CAS 2167007-41-0)
- 3-(5-(Chloromethyl)-1,2,4-oxadiazol-3-yl)benzonitrile (CAS 660416-40-0)
- N-((1-aminocyclohexyl)methyl)acetamide hydrochloride (CAS 1713160-62-3)
- N-Methoxy-N,3-dimethyl-4-nitrobenzamide (CAS 1221342-55-7)
- Methylionene (CAS 31197-54-3)
- (4-Chlorophenyl)methanesulfonyl fluoride (CAS 1513-29-7)
- Tetrahydropyran-3-carbonitrile (CAS 89464-26-6)
- N-(6-(1H-Indazol-5-yl)naphthalen-2-yl)thiophene-3-carboxamide (CAS 919363-15-8)
- Tetrahydro-α-hydroxy-3-furanacetonitrile (CAS 1155915-36-8)
- 2-(4-Aminophenyl)-5-heptadecyl-1-methyl-1H-pyrazol-3(2H)-one (CAS 194799-55-8)
- S-(-)-7-Desmethyl-8-nitro Blebbistatin (CAS 856925-75-2)
- Insulin Degludec Impurity 8 (CAS CATO-C4X-21578)
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