1-Chloro-4-(1-iodoethyl)benzene CAS 495405-71-5
| CAS No. | 495405-71-5 |
| Molecular Formula | C8H8ClI |
| Molecular Weight | 266.51 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
1-Chloro-4-(1-iodoethyl)benzene (CAS 495405-71-5), molecular formula C8H8ClI and molecular weight 266.51 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 1-Chloro-4-(1-iodoethyl)benzene (C8H8ClI) is characterized by chlorine/iodine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H8ClI |
| Molecular Weight | 266.51 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl/I-containing |
Related Chloro Standards
- 4-Chloro-2-iodo-m-xylene (CAS 1208078-09-4)
- 1-Chloro-2-ethyl-3-iodobenzene (CAS 1369876-61-8)
- 2-Chloro-1-ethyl-4-iodobenzene (CAS 1369923-71-6)
- 1-Chloro-3-(1-iodoethyl)benzene (CAS 1799405-26-7)
- 1-Chloro-2-(1-iodoethyl)benzene (CAS 1799405-28-9)
- 1-Chloro-2-iodo-4,5-dimethylbenzene (CAS 755758-89-5)
- 1-Chloro-4-iodo-2,3-dimethylbenzene (CAS 2385537-79-9)
- 1-Chloro-4-iodo-2,5-dimethylbenzene (CAS 854861-39-5)
Recommended Standards
- 1-(Chloromethyl)-3-iodo-5-methylbenzene (CAS 940099-31-0)
- 1-(1-Chloroethyl)-4-iodobenzene (CAS 58114-08-2)
- 2,6,10,14-Tetramethylpentadec-1-ene (CAS 2140-82-1)
- (S)-14-Methyl-1-octadecene (CAS 99493-42-2)
- (7R,8S)-7,8-Diaminononanoic acid dihydrochloride (CAS 951786-35-9)
- 0715AE 2-({2-[(4-Methylbenzyl)amino]-2-oxoethyl}sulfanyl) acetic acid 338421-46-8 C12H15NO3S (CAS 338421-46-8)
- Dimethyl 2,5-dichloroterephthalate (CAS 3293-89-8)
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- (9'Z,9''Z)-(2R,3R,4S,5R,6R)-2-(((2R,3S,4S,5R)-3,4-Dihydroxy-2,5-bis(hydroxymethyl)tetrahydrofuran-2-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triyl trioleate (CAS 52701-72-1)
- 2,5-Dimethylpyrazolidin-3-one (CAS 54945-11-8)
- (2-Methoxy-5-(trimethylsilyl)phenyl)boronic acid (CAS 1338383-00-8)
- 3-methyl-1H-pyrrolo[2,3-b]pyridine-5-carbaldehyde (CAS 1211516-12-9)
- Semaglutide impurity 58 (CAS CATO-C4X-222658)
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