4-Methylbenzene-1,3-diol CAS 496-73-1
| CAS No. | 496-73-1 |
| Molecular Formula | C20H33N3O3 |
| Molecular Weight | 363.49 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
4-Methylbenzene-1,3-diol (CAS 496-73-1), molecular formula C20H33N3O3 and molecular weight 363.49 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, 4-Methylbenzene-1,3-diol (C20H33N3O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 6.0, corresponding to approximately 6 ring(s) or double-bond equivalent(s). With a molecular weight of 363.49 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a certified reference material (CRM), 4-Methylbenzene-1,3-diol meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C20H33N3O3 |
| Molecular Weight | 363.49 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Nitrogen Atoms | 3 |
Related Methylbenzene Standards
- N1-methylbenzene-1,2-diamine hydrochloride (CAS 81684-80-2)
- 1-[(4-Methylbenzene)sulfonyl]-2-nitro-1H-indole (CAS 1491230-49-9)
- 3-methylbenzene-1,2-disulfonyl dichloride (CAS 116465-26-0)
- 4-Methylbenzene-1,3-disulfonyl dichloride (CAS 2767-77-3)
- 1-[(4-Methylbenzene)sulfonyl]-1H-indol-2-ol (CAS 1881290-33-0)
- 4-methylbenzene-1-sulfonyl iodide (CAS 1950-78-3)
- Methyl 1-[(4-methylbenzene)sulfonyl]azetidine-3-carboxylate (CAS 1820684-87-4)
- 1-[(4-Methylbenzene)sulfonyl]-2-nitro-1H-pyrrole (CAS 128080-58-0)
Recommended Standards
- Abiraterone Impurity 75 (CAS 1416316-29-4)
- RMC6236 Intermediate 20 (CAS CATO-CIM-103908)
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- N-((RS)-2-Hydroxy-propyl)-Val-Leu-anilide (CAS 282726-24-3)
- 4'-Ethoxy-[1,1'-biphenyl]-3-carbaldehyde (CAS 118350-18-8)
- rel-(2R,3R)-1-Methyl-6-oxo-2-phenyl-3-piperidinecarboxylic acid (CAS 1218344-45-6)
- 6-Bromo-7-fluoro-1H-benzo[d][1,2,3]triazole (CAS 1588508-95-5)
- (2,6-difluorophenyl)methanesulfonamide (CAS 256651-60-2)
- 2-azido-1-(thiophen-2-yl)ethan-1-one (CAS 36031-67-1)
- 1,1'-(((Ethane-1,2-diylbis(oxy))bis(4,1-phenylene))bis(methylene))bis(4-(dimethylamino)pyridin-1-ium) bromide (CAS 1839150-63-8)
- 7-Chloro-2-methyl-2H-benzo[b][1,4]oxazin-3(4H)-one (CAS 1506636-10-7)
- 1-Bromo-9-iodoanthracene (CAS 820208-66-0)
- [1-(triphenylmethyl)-1h-1,2,3,4-tetrazol-5-yl]methanamine (CAS 885278-28-4)
- Semaglutide impurity 27 (CAS CATO-C4X-222627)
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