4-((2-Chloro-6-fluorobenzylidene)amino)-3-(3-ethoxyphenyl)-1H-1,2,4-triazole-5(4H)-thione CAS 497921-66-1
| CAS No. | 497921-66-1 |
| Molecular Formula | C17H14ClFN4OS |
| Molecular Weight | 376.84 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-((2-Chloro-6-fluorobenzylidene)amino)-3-(3-ethoxyphenyl)-1H-1,2,4-triazole-5(4H)-thione.
4-((2-Chloro-6-fluorobenzylidene)amino)-3-(3-ethoxyphenyl)-1H-1,2,4-triazole-5(4H)-thione (CAS 497921-66-1), molecular formula C17H14ClFN4OS and molecular weight 376.84 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 4-((2-Chloro-6-fluorobenzylidene)amino)-3-(3-ethoxyphenyl)-1H-1,2,4-triazole-5(4H)-thione (C17H14ClFN4OS) is characterized by a steroid core, an amide group, sulfur-containing functionality, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 4-((2-Chloro-6-fluorobenzylidene)amino)-3-(3-ethoxyphenyl)-1H-1,2,4-triazole-5(4H)-thione meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C17H14ClFN4OS |
| Molecular Weight | 376.84 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 4 |
| Sulfur Atoms | 1 |
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Recommended Standards
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- (3E)-1-[(4-Chlorophenyl)methyl]-3-[(4-methoxyphenyl)imino]-2,3-dihydro-1H-indol-2-one (CAS 478031-80-0)
- N-((4-(3-Chlorophenyl)-5-(methylthio)-4H-1,2,4-triazol-3-yl)methyl)-3-fluorobenzamide (CAS 391899-74-4)
- (E)-Naftifine (CAS 65472-88-0)
- Methyl 3-<I>p</I>-tolyl-1<I>H-</I>pyrazole-5-carboxylate (CAS 192701-73-8)
- 4-(3-Azetidinylmethyl)-1-methyl-1H-pyrazole Dihydrochloride (CAS 2031261-15-9)
- 5-(Methylsulfonyl)-4-phenyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile (CAS 1447960-57-7)
- 6-Methoxy-4-methylquinoline-2-thiol (CAS 52323-10-1)
- 1-(4-Methoxyphenyl)-1-methylhydrazine (CAS 35292-54-7)
- Perhexiline (CAS 6621-47-2)
- 1-methyl-3-(m-tolyl)-1H-pyrazol-5-amine (CAS 1017665-60-9)
- 1-Benzyl-1H-indazol-6-amine (CAS 51336-56-2)
- Pheromone Biosynthesis Activating Neuropeptide (Helicoverpa assulta, Heliothis zea) (CAS 122071-54-9)
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