Clomipramine EP Impurity B CAS 50-49-7
| CAS No. | 50-49-7 |
| Molecular Formula | C19H24N2 |
| Molecular Weight | 280.41 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Clomipramine EP Impurity B.
CATO supplies Clomipramine EP Impurity B (CAS 50-49-7), a pharmacopoeial impurity reference standard (molecular formula C19H24N2, MW 280.41 g/mol) used for the identification and quantification of trace impurities in APIs.
Based on its molecular formula C19H24N2, Clomipramine EP Impurity B contains a nitrogen-containing heterocyclic scaffold, a nitrile group; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 280.41 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C19H24N2 |
| Molecular Weight | 280.41 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Nitrogen Atoms | 2 |
Related Clomipramine Standards
- Clomipramine Impurity 3 (CAS 79752-03-7)
- Clomipramine Impurity 2 (CAS 25961-11-9)
- Clomipramine Hydrochloride EP Impurity C (CAS 1425793-87-8)
- Clomipramine Impurity 10 (CAS 95021-06-0)
- Clomipramine Impurity 11 (CAS 78213-40-8)
- Clomipramine Impurity 9 (CAS CATO-C4X-12659)
- Clomipramine Impurity 4 (CAS 84803-67-8)
- Clomipramine EP Impurity C (CAS 2095-42-3)
Recommended Standards
- Repaglinide Impurity 14 (CAS 107362-46-9)
- Bamipine (CAS 4945-47-5)
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- H-Met-Met-OH (CAS 7349-78-2)
- Trimebutine Impurity 28 (CAS CATO-C4X-185828)
- Hyoscine EP Impurity C（R-isomer） (CAS 17126-67-9)
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- 2-Amino-N-(furan-2-ylmethyl)-4-methylthiazole-5-sulfonamide (CAS 1480388-03-1)
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