(R)-3-((tert-Butoxycarbonyl)amino)-3-(4-nitrophenyl)propanoic acid CAS 500770-85-4
| CAS No. | 500770-85-4 |
| Molecular Formula | C14H18N2O6 |
| Molecular Weight | 310.30 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
(R)-3-((tert-Butoxycarbonyl)amino)-3-(4-nitrophenyl)propanoic acid (CAS 500770-85-4) is a high-purity analytical reference standard with the molecular formula C14H18N2O6 and a molecular weight of 310.30 g/mol.
The molecular framework of (R)-3-((tert-Butoxycarbonyl)amino)-3-(4-nitrophenyl)propanoic acid (C14H18N2O6) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H18N2O6 |
| Molecular Weight | 310.30 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1984 |
| Nitrogen Atoms | 2 |
Recommended Standards
- (R)-3-((tert-Butoxycarbonyl)amino)-3-(2-nitrophenyl)propanoic acid (CAS 501015-23-2)
- (S)-3-((tert-Butoxycarbonyl)amino)-3-(2-nitrophenyl)propanoic acid (CAS 500770-83-2)
- (2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl cinnamate (CAS 40004-96-4)
- (S)-3-((Tert-butoxycarbonyl)amino)-3-(4-nitrophenyl)propanoic acid (CAS 499995-73-2)
- (1S)-3,3′-Bis([1,1′-biphenyl]-4-yl)-5,5′,6,6′,7,7′,8,8′-octahydro[1,1′-binaphthalene]-2,2′-diol (CAS 2757287-34-4)
- Allyl(4-(tert-butyl)phenyl)sulfane (CAS 157581-05-0)
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- 2-{2-[(4-methoxyphenyl)formamido]acetamido}ethyl 3-(2-chloro-6-fluorophenyl)-5-methyl-1,2-oxazole-4-carboxylate (CAS 338419-61-7)
- 1-{[(3-fluoropyridin-2-yl)oxy]methyl}cyclopentan-1-amine (CAS 1344288-19-2)
- (4,6-Dimethylpyrimidin-5-yl)(4-((S)-4-((R)-2-methoxy-1-(4-(trifluoromethyl)phenyl)ethyl)-3-methylpiperazin-1-yl)-4-methylpiperidin-1-yl)methanone hydrochloride (CAS 541503-48-4)
- Semaglutide impurity 51 (CAS CATO-C4X-222651)
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