Sildenafil Impurity 6 CAS 501120-42-9
| CAS No. | 501120-42-9 |
| Molecular Formula | C17H19ClN4O4S |
| Molecular Weight | 410.88 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO supplies Sildenafil Impurity 6 (CAS 501120-42-9), a pharmacopoeial impurity reference standard (molecular formula C17H19ClN4O4S, MW 410.88 g/mol) used for the identification and quantification of trace impurities in APIs.
Sildenafil Impurity 6 (C17H19ClN4O4S) contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C17H19ClN4O4S |
| Molecular Weight | 410.88 g/mol |
| Purity | >80% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1984 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
| Sulfur Atoms | 1 |
Related Sildenafil Standards
- Sildenafil Impurity 7 (CAS 139756-22-2)
- Sildenafil Impurity 79 (CAS CATO-C4X-112879)
- Sildenafil Impurity 68 (CAS CATO-C4X-112868)
- Sildenafil Impurity 15 (CAS 2512206-40-3)
- Sildenafil Impurity 269 (CAS CATO-C4X-1128269)
- Sildenafil Impurity 292 (CAS CATO-C4X-1128292)
- Sildenafil Impurity 38 (CAS 319491-68-4)
- Sildenafil Impurity 102 (CAS CATO-C4X-1128102)
Recommended Standards
- Methyl 4-amino-3-(4-(4-chlorophenyl)thiazol-2-yl)-1-phenyl-1h-pyrazole-5-carboxylate (CAS 878260-11-8)
- 4-Ethoxy-3-(5-methyl-4-oxo-7-propyl-3,4-dihydro-imidazo[5,1-f][1,2,4]-triazin-2-yl)benzene-sulfonyl Chloride (CAS 224789-26-8)
- 2-Formyl Loratadine (CAS 1076198-15-6)
- 3-Amino-N-(5-chloro-2-methoxyphenyl)-6-(pyridin-4-yl)thieno[2,3-b]pyridine-2-carboxamide (CAS 445267-38-9)
- Abemaciclib Impurity 186 (CAS 2137067-02-6)
- Acotiamide Impurity 7 (CAS CATO-C4X-11147)
- Tocopherol impurity 37 (CAS 185672-33-7)
- 2-(Methylsulfonyl)-4-phenylpyrimidine-5-carbonitrile (CAS 89079-63-0)
- 4-(tert-Butyl)-2-(2-cyanopropan-2-yl)phenyl methyl carbonate (CAS 1246213-37-5)
- 4,4'-(1H,1'H-[2,2'-Biimidazole]-1,1'-diyl)dibenzoic acid (CAS 2413962-77-1)
- 1-Benzyl-4-hydroxy-1H-imidazole-5-carboxamide (CAS 82439-85-8)
- t-BuXphos Palladacycle Gen. 4 (CAS 1599466-89-3)
- 5-Chloro-1-cyclopropyl-1H-indole (CAS 1021154-57-3)
- Semaglutide Impurity 185 (CAS CATO-C4X-2226185)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com