4-Cyano-N-(2-methoxyphenyl)-3-methyl-5-(2-phenoxyacetamido)thiophene-2-carboxamide CAS 503864-33-3
| CAS No. | 503864-33-3 |
| Molecular Formula | C22H19N3O4S |
| Molecular Weight | 421.47 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
4-Cyano-N-(2-methoxyphenyl)-3-methyl-5-(2-phenoxyacetamido)thiophene-2-carboxamide (CAS 503864-33-3), molecular formula C22H19N3O4S and molecular weight 421.47 g/mol, is a CATO reference standard with documented purity and traceability.
4-Cyano-N-(2-methoxyphenyl)-3-methyl-5-(2-phenoxyacetamido)thiophene-2-carboxamide (C22H19N3O4S) contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), 4-Cyano-N-(2-methoxyphenyl)-3-methyl-5-(2-phenoxyacetamido)thiophene-2-carboxamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H19N3O4S |
| Molecular Weight | 421.47 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1984 |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Cyano Standards
- 2-((3-Cyano-4,6-diphenylpyridin-2-yl)thio)-N-phenylacetamide (CAS 332040-65-0)
- 2-((5-Cyano-4-(trifluoromethyl)-[2,4'-bipyridin]-6-yl)thio)-N-(thiazol-2-yl)acetamide (CAS 625378-16-7)
- N-((2-Cyano-4-(neopentylamino)pyrimidin-5-yl)methyl)-4-(4-methylpiperazin-1-yl)benzamide (CAS 501000-36-8)
- O-(3-Cyano-6-(thiophen-2-yl)-4-(trifluoromethyl)pyridin-2-yl) O,O-diethyl phosphorothioate (CAS 286435-85-6)
- 2-{[3-cyano-6-methyl-4-(thiophen-3-yl)-5,6,7,8-tetrahydro-1,6-naphthyridin-2-yl]sulfanyl}-N-phenylacetamide (CAS 340813-92-5)
- N-(1-Cyano-1-cyclopropylethyl)-2-((1-(4-ethoxyphenyl)-1H-benzo[d]imidazol-2-yl)thio)acetamide (CAS 850019-40-8)
- N-(2-Cyano-3-methylbutan-2-yl)-2-((5-(pyridin-3-yl)-4-(o-tolyl)-4H-1,2,4-triazol-3-yl)thio)acetamide (CAS 731816-21-0)
- (R)-4-Cyano-N-(1-(1-ethyl-6-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)ethyl)benzenesulfonamide (CAS 1025506-51-7)
Recommended Standards
- 4-[3-Methoxy-3-oxo-2-(1-oxo-2,3-dihydro-1H-isoindol-2-yl)propyl]phenyl thiophene-2-carboxylate (CAS 477889-65-9)
- 4-Nitro-N-(2-(2-phenyl-1H-indol-3-yl)ethyl)benzenesulfonamide (CAS 648894-21-7)
- (R)-Bn-Phox (CAS 314020-70-7)
- 9-Butyl-8-((3,4,5-trimethoxyphenyl)sulfonyl)-9H-purin-6-amine (CAS 827302-63-6)
- 2-Ethoxy-N-(4-fluoro-3-methylbenzyl)ethan-1-amine (CAS 1249614-19-4)
- 3,3,3-Trifluoropropane-1-sulfonyl Chloride (CAS 845866-80-0)
- 1-(2-Fluorophenyl)-4-methylcyclohexan-1-ol (CAS 1249645-54-2)
- 1-(Benzyloxy)-3-(chloromethyl)-5-nitrobenzene (CAS 1393576-95-8)
- N1-[3,5-di(trifluoromethyl)phenyl]-6-chlorohexanamide (CAS 647824-81-5)
- β-Asp5-Carbetocin (CAS CATO-C4X-191130)
- Lacidipine Impurity 17 (CAS CATO-C4X-167117)
- (1E)-3,4-Dihydrophenazin-1(2H)-one oxime (CAS 42272-79-7)
- Ethyl 2-(2-aminoethyl)thiazole-4-carboxylate (CAS 64515-80-6)
- Semaglutide impurity 43 (CAS CATO-C4X-222643)
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