Prednisolone impurity 64 CAS 50557-66-9
| CAS No. | 50557-66-9 |
| Molecular Formula | C23H26O4 |
| Molecular Weight | 366.45 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Prednisolone impurity 64 (CAS 50557-66-9) is a certified pharmaceutical impurity reference standard with the molecular formula C23H26O4 and a molecular weight of 366.45 g/mol.
Owing to a flavonoid core, a hydroxyl group, an ether linkage, Prednisolone impurity 64 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 366.45 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C23H26O4 |
| Molecular Weight | 366.45 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1971 |
Related Prednisolone Standards
- Prednisolone impurity 55 (CAS CATO-C4X-173755)
- Prednisolone-D6 (CAS CATO-C4X-191930)
- Prednisolone-d8 (Major) (CAS CATO-C4X-191924)
- Prednisolone-d8 (CAS CATO-CCAD302219)
- Prednisolone-d8 (CAS CATO-LCAD302219-ME)
- Prednisolone 20alpha-Hydroxy Impurity (CAS 15847-24-2)
- Prednisolone EP Impurity G (CAS 2299-46-9)
- Prednisolone impurity 65 (CAS 20380-15-8)
Recommended Standards
- Warfarin impurity 19 (CAS CATO-C4X-17819)
- Rosuvastatin Impurity 241 (CAS CATO-C4X-1169241)
- Vinpocetine Impurity 29 (CAS CATO-C4X-184329)
- Canagliflozin Impurity 97 (CAS CATO-C4X-112397)
- Eribulin Impurity 13 (CAS CATO-C4X-265013)
- Ganirelix lmpurity 7 (CAS CATO-C4X-23737)
- Afoxolaner Impurity 10 (CAS CATO-C4X-313710)
- 3-Amino-3-cyclohexylbutanoic acid (CAS 1270444-33-1)
- 3,5-Dichloro-4-formylphenylboronic acid (CAS 1451393-36-4)
- 1,2,3,4-Tetrahydroquinoxaline-6-carbonitrile (CAS 744971-10-6)
- 2,3-Naphthalenedicarbonitrile 22856-30-0 naphthalene-2,3-dicarbonitrile (CAS 22856-30-0)
- (3-(tert-Butyl)isoxazol-4-yl)methanamine (CAS 1512219-81-6)
- 2-Amino-3,3-difluoro-2-methylpropanoic acid hydrochloride (CAS 67654-64-2)
- Semaglutide impurity 204 (CAS CATO-C4X-2226204)
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