2-(Iodomethyl)-5-methoxy-2,3-dihydrobenzofuran CAS 508168-22-7
| CAS No. | 508168-22-7 |
| Molecular Formula | C10H11IO2 |
| Molecular Weight | 290.10 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-(Iodomethyl)-5-methoxy-2,3-dihydrobenzofuran.
2-(Iodomethyl)-5-methoxy-2,3-dihydrobenzofuran (CAS 508168-22-7), molecular formula C10H11IO2 and molecular weight 290.10 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, iodine substitution, an aromatic ring system, 2-(Iodomethyl)-5-methoxy-2,3-dihydrobenzofuran is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 290.10 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H11IO2 |
| Molecular Weight | 290.10 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1984 |
| Halogen Content | I-containing |
Related Iodomethyl Standards
- 2-(Iodomethyl)-1,1,1,3,3,3-hexafluoropropane (CAS 883449-40-9)
- 2-(Iodomethyl)-1,1,1,3,3,3-hexafluoropropane (CAS 883499-40-9)
- 1-(iodomethyl)-4-(trifluoromethyl)-2-oxabicyclo[2.1.1]hexane (CAS 2287288-10-0)
- 2-(Iodomethyl)-5-phenyloxolane (CAS 36842-33-8)
- 5-(iodomethyl)-2-phenyl-4,5-dihydro-1,3-oxazole (CAS 200573-05-3)
- (3S)-3-(iodomethyl)-3,4-dihydro-2H-isoquinolin-1-one (CAS 1057341-36-2)
- 1-(Iodomethyl)-4-(trifluoromethyl)benzene (CAS 207388-61-2)
- 4-(Iodomethyl)-2-phenyloxazole (CAS 33162-08-2)
Recommended Standards
- 2-(Cyclopropylmethoxy)-3-iodophenol (CAS 944334-09-2)
- 2-Amino-5-iodo-N,N-dimethylbenzamide (CAS 960067-72-5)
- 2-(4-Iodophenyl)-2-methylpropanoic acid (CAS 228410-36-4)
- 2-Bromo-1-(3,4-dihydroisoquinolin-2(1H)-yl)-2,2-difluoroethan-1-one (CAS 672949-77-8)
- 3-Acryloyl-2-oxazolidinone (CAS 2043-21-2)
- Procaine Hydrochloride (CAS 51-05-8)
- Ethyl 4-chloro-2-hydroxybenzoate (CAS 52873-25-3)
- (1S,3S)-3-(trifluoromethyl)-8-azaspiro[4.5]Decan-1-amine dihydrochloride (CAS 2306253-17-6)
- Chlormidazole HCl (CAS 74298-63-8)
- N-(3-chloro-4-methoxybenzyl)-3-(trifluoromethyl)benzamide (CAS 478259-44-8)
- Drospirenone Impurity N1 (CAS 82543-15-5)
- 1-(2-(4-Bromo-1h-pyrazol-1-yl)ethyl)-1h-pyrazol-3-amine (CAS 1344099-44-0)
- Isopropyl 6-hydroxy-5-nitronicotinate (CAS CATO-C3D-263212)
- (Glu9)-Exenatide (2-39) trifluoroacetate salt (CAS 196109-34-9)
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