Tizanidine EP Impurity B CAS 51323-05-8
| CAS No. | 51323-05-8 |
| Molecular Formula | C7H5ClN4S2 |
| Molecular Weight | 244.72 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Tizanidine EP Impurity B is closely related to a nitrile group, sulfur-containing functionality, chlorine substitution, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Tizanidine EP Impurity B (CAS 51323-05-8) is a certified pharmaceutical impurity reference standard with the molecular formula C7H5ClN4S2 and a molecular weight of 244.72 g/mol.
Tizanidine EP Impurity B (C7H5ClN4S2) contains a nitrile group, sulfur-containing functionality, chlorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Tizanidine EP Impurity B meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H5ClN4S2 |
| Molecular Weight | 244.72 g/mol |
| Purity | >90% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1971 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
| Sulfur Atoms | 2 |
Related Tizanidine Standards
- Tizanidine impurity 32 (CAS CATO-C4X-144532)
- Tizanidine impurity 17 (CAS CATO-C4X-144517)
- Tizanidine impurity 33 (CAS CATO-C4X-144533)
- Tizanidine impurity 28 (CAS CATO-C4X-144528)
- Tizanidine Impurity 41 (CAS CATO-C4X-144541)
- Tizanidine Impurity 42 (CAS CATO-C4X-144542)
- Tizanidine (CAS 51322-75-9)
- Tizanidine impurity 25 (CAS CATO-C4X-144525)
Recommended Standards
- Lercanidipine Impurity 42 (CAS 37089-77-3)
- 1-(2-Chloroethyl)-3-(3-(methylthio)phenyl)urea (CAS 102433-61-4)
- Chlorphenamine Impurity 43 (CAS CATO-C4X-118843)
- 1-(5-Chlorothiophen-2-yl)-4,4-dimethylpentane-1,3-dione (CAS 1154905-55-1)
- Atrasentan Impurity 150 (CAS 1058402-39-3)
- Tinidazole Impurity 4 (CAS 13230-19-8)
- Prusogliptin Impurity 15 (CAS CATO-C4X-328415)
- 2-(Carbazol-9-yl)benzonitrile (CAS 1383957-80-9)
- 1-(Aminomethyl)cyclobutanamine hydrochloride (CAS 1923052-25-8)
- 6-Methyl-N-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridyl]pyridine-2-carboxamide (CAS 2246657-34-9)
- ent-9-Desmethyl-alpha-Dihydro-Tetrabenazine (CAS 1065193-41-0)
- 5-(Thiophen-3-yl)-1H-pyrrole-2-carboxylic acid (CAS 72078-42-3)
- N-(2-chlorobenzyl)-1,3,4-thiadiazol-2-amine (CAS 1340448-44-3)
- Semaglutide impurity 99 (CAS CATO-C4X-222699)
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