Methyl (E)-3-chloroacrylate CAS 5135-18-2
| CAS No. | 5135-18-2 |
| Molecular Formula | C4H5ClO2 |
| Molecular Weight | 120.53 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Methyl (E)-3-chloroacrylate.
Methyl (E)-3-chloroacrylate (CAS 5135-18-2), molecular formula C4H5ClO2 and molecular weight 120.53 g/mol, is a CATO reference standard with documented purity and traceability.
Methyl (E)-3-chloroacrylate (C4H5ClO2) contains a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), Methyl (E)-3-chloroacrylate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C4H5ClO2 |
| Molecular Weight | 120.53 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | Cl-containing |
Recommended Standards
- Cyclopropyl Carbonochloridate (CAS 52107-21-8)
- Methyl (Z)-3-chloroacrylate (CAS 3510-44-9)
- Allyl Chloroformate (CAS 2937-50-0)
- Methyl-a-chloroacrylate (CAS 80-63-7)
- 1-[(5-Bromothien-2-yl)sulfonyl]piperidine-3-carboxylic acid (CAS 496778-03-1)
- Methyl 3-(2-fluorophenyl)oxirane-2-carboxylate (CAS 1287218-43-2)
- (3-Benzylphenyl)hydrazine (CAS 734505-16-9)
- (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-6-((tert-butoxycarbonyl)amino)-2-methylhexanoic acid (CAS 1315449-94-5)
- H-Leu-Trp-Met-Arg-Phe-OH (CAS 67201-39-2)
- 2-(Aminomethyl)-4-bromo-6-(difluoromethyl)pyridine-3-carboxylic acid (CAS 1804667-32-0)
- Lithium propionate (CAS 6531-45-9)
- 2-Chloro-4-(chloromethyl)-5-(difluoromethyl)nicotinaldehyde (CAS 1805366-11-3)
- Amphotericin B Impurity 24 (CAS CATO-C4X-184424)
- Semaglutide impurity 290 (CAS CATO-C4X-2226290)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com