Naloxone hydrochloride dihydrate CRS CAS 51481-60-8
| CAS No. | 51481-60-8 |
| Molecular Formula | C19H21NO4 |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Naloxone hydrochloride dihydrate CRS.
Naloxone hydrochloride dihydrate CRS (CAS 51481-60-8), molecular formula C19H21NO4HClH2O and molecular weight 381.85 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, Naloxone hydrochloride dihydrate CRS (C19H21NO4HClH2O) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 8.0, corresponding to approximately 8 ring(s) or double-bond equivalent(s). With a molecular weight of 381.85 g/mol, it falls into the moderately-high-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C19H21NO4 HCl 2*H2O |
| Molecular Weight | 381.85 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1971 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Naloxone Standards
- Naloxone Impurity 21 (CAS 119630-94-3)
- Naloxone-D5 (CAS 1261079-38-2)
- Naloxone-d5 3-Methyl Ether (1.0mg/ml in Acetonitrile) (CAS 1261082-21-6)
- Naloxone Hydrochloride EP Impurity B (CAS 1352085-46-1)
- Naloxone-d5 HCl (CAS 1426174-78-8)
- Naloxone Impurity 18 (CAS 156047-22-2)
- Naloxone Hydrochloride EP Impurity E (CAS 211738-08-8)
- Naloxone Hydrochloride EP Impurity C (CAS 2139253-68-0)
Recommended Standards
- 2-(3-Benzyl-2,5-dioxopyrrolidin-1-yl)acetic acid (CAS 332849-43-1)
- 4-(Dimethylamino)-2-nitrobenzaldehyde (CAS 56670-20-3)
- Bis{4-[(1E)-3-oxo-3-phenylprop-1-en-1-yl]phenyl} pentanedioate (CAS 331459-94-0)
- 2-Fluoro-3-(methylsulfanyl)phenylboronic acid (CAS 1451392-57-6)
- 2-Furoylacetonitrile 3-Furan-2-yl-3-oxo-propionitrile 31909-58-7 A5750 (CAS 31909-58-7)
- 2-(Ethylamino)-2-methyl-4-(1h-1,2,4-triazol-1-yl)pentanamide (CAS 1342373-23-2)
- 1-(2,4-Dihydroxyphenyl)-2-(4-methoxyphenoxy)ethan-1-one (CAS 121361-55-5)
- N-Methyl-2-(1-phenylvinyl)aniline (CAS 133363-43-6)
- Fluorometholone Epoxy Analog (CAS 83873-17-0)
- Tau Peptide (306-336) (Repeat 3 Domain) trifluoroacetate salt (CAS 330456-26-3)
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