4-Chloropyridine-3-sulfonic acid CAS 51498-38-5
| CAS No. | 51498-38-5 |
| Molecular Formula | C5H4ClNO3S |
| Molecular Weight | 193.61 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 193.61 g/mol gives 4-Chloropyridine-3-sulfonic acid distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
4-Chloropyridine-3-sulfonic acid (CAS 51498-38-5), molecular formula C5H4ClNO3S and molecular weight 193.61 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 4-Chloropyridine-3-sulfonic acid (C5H4ClNO3S) is characterized by an amide group, a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C5H4ClNO3S |
| Molecular Weight | 193.61 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1971 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Chloropyridine Standards
- 2-Chloropyridine-4-sulfonic acid (CAS 1209458-81-0)
- 6-Chloropyridine-2-sulfonic acid (CAS 133145-15-0)
- 6-Chloropyridine-3-sulfonic acid (CAS 17624-08-7)
- 2-Chloropyridine-3-sulfonic acid (CAS 6602-56-8)
- 5-Chloropyridine-3-sulfonamide (CAS 1334148-60-5)
- 6-chloropyridine-2-sulfonamide (CAS 1823272-65-6)
- 5-Chloropyridine-2-sulfonamide (CAS 19506-41-3)
- 3-Chloropyridine-2-sulfonamide (CAS 96009-29-9)
Recommended Standards
- 5-chloropyrimidine-2-sulfonamide (CAS 873398-77-7)
- (2,4-DIOXO-1,3-THIAZOLIDIN-5-YL)ACETYL CHLORIDE 51226-17-6 (CAS 51226-17-6)
- Vonoprazan Impurity 170 (CAS 2358783-64-7)
- 2-chloro-6-fluoro-3H-pyrrolo[2,1-f][1,2,4]triazin-4-one (CAS 2306269-84-9)
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- 3-Amino-4,6-dimethyl-thieno[2,3-b]pyridine-2-carbonitrile (CAS 52505-57-4)
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- 2H-Isoindole-1-sulfonic acid (CAS 569650-95-9)
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